Bodis-Wollner I, Yahr M D
Brain. 1978 Dec;101(4):661-71. doi: 10.1093/brain/101.4.661.
Visual evoked potentials elicited by reversing grating patterns were recorded in 35 patients with Parkinson's disease and in 26 controls. The average latency of evoked potentials in patients with Parkinson's disease exceeded by two standard deviations the average of the age-matched control group of other neurological patients. Over two-thirds of all patients with Parkinson's disease had abnormal latency. In these patients latency did not correlate with age. In 5 patients the latency became less prolonged on levodopa therapy, suggesting that catecholaminergic pathways have either indirect or direct effects on the generation of visual evoked potentials. Extrapyramidal connections of the visual cortex, as well as retinal dopaminergic neurons, require further study in Parkinson's disease.
对35例帕金森病患者和26名对照者记录了由反转光栅图案诱发的视觉诱发电位。帕金森病患者诱发电位的平均潜伏期比其他神经系统疾病患者年龄匹配的对照组平均值超出两个标准差。超过三分之二的帕金森病患者潜伏期异常。在这些患者中，潜伏期与年龄无关。5例患者在左旋多巴治疗后潜伏期缩短，提示儿茶酚胺能通路对视觉诱发电位的产生有间接或直接作用。视觉皮层的锥体外系联系以及视网膜多巴胺能神经元在帕金森病中需要进一步研究。
