偏侧帕金森病中手动运动的准备
Preparation of manual movements in hemiparkinsonism.
作者信息
Rafal R D, Friedman J H, Lannon M C
机构信息
Department of Clinical Neurosciences, Roger Williams General Hospital, Providence, RI 02908.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):399-402. doi: 10.1136/jnnp.52.3.399.
Twenty patients with asymmetric Parkinson's disease were studied in a reaction time (RT) experiment in which the performance of the more affected ("bad") hand was compared with performance of the less affected ("good") hand. Simple RT and choice RT were tested in separate blocks, and the benefit afforded by advance information in the simple RT condition (choice RT minus simple RT) served as a measure of motor preparation. RT was longer in the "bad" hand in both the simple RT and choice RT conditions. There was no difference in the effect of advance information between the two hands. It is concluded that slowness in RT movement initiation in Parkinson's disease is not due to a deficiency in motor preparation, and that intact basal ganglia function is not required for this stage of motor programming.
在一项反应时（RT）实验中，对20名非对称性帕金森病患者进行了研究，该实验比较了受影响较重（“患侧”）手与受影响较轻（“健侧”）手的表现。简单反应时和选择反应时在不同的组块中进行测试，简单反应时条件下提前信息带来的益处（选择反应时减去简单反应时）作为运动准备的一项指标。在简单反应时和选择反应时条件下，“患侧”手的反应时均更长。两只手在提前信息的影响方面没有差异。得出的结论是，帕金森病中反应时运动起始的迟缓并非由于运动准备不足，并且运动编程的这一阶段不需要完整的基底神经节功能。
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