Stelmach G E, Worringham C J
Motor Behavior Laboratory, University of Wisconsin-Madison.
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):223-31. doi: 10.1136/jnnp.51.2.223.
The control of unimanual and bimanual aiming movements by Parkinson's disease and control subjects was examined. Despite greater bimanual movement initiation asynchrony and overall bradykinesia, the Parkinson's disease subjects were affected by the experimental manipulations in the same way as controls. Symmetrical and, more especially, asymmetrical bimanual movements required more preparation time and were executed more slowly by both groups than were unimanual movements. Both groups also showed temporal linkage of movements to targets of different extents--movements which have different movement times when performed unimanually, as well as of the faster and slower limbs. A majority in both groups over-compensated for asynchrony in bimanual movement initiation by modulation of movement times, but there was no group difference in this tendency. The results are discussed in terms of underlying motor control processes and with regard to previous evidence for impaired control of simultaneous movements in Parkinson's disease.
研究了帕金森病患者和对照组对单手及双手瞄准动作的控制情况。尽管帕金森病患者双手动作起始的异步性更大且存在整体运动迟缓，但他们受实验操作的影响方式与对照组相同。与单手动作相比，对称的、尤其是不对称的双手动作需要更多准备时间，且两组执行速度均较慢。两组还均表现出动作与不同距离目标的时间关联——这些目标在单手执行时具有不同的运动时间，以及较快和较慢肢体的时间关联。两组中的大多数人通过调节运动时间来过度补偿双手动作起始的异步性，但在这种趋势上没有组间差异。根据潜在的运动控制过程以及帕金森病患者同时运动控制受损的先前证据对结果进行了讨论。
