Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5090000, Chile.
Escuela de Tecnología Medica, Universidad Austral de Chile, Sede Puerto Montt 5480000, Chile.
Molecules. 2017 Dec 21;23(1):0014. doi: 10.3390/molecules23010014.
Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the Burkitt's lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity.
白藜芦醇是一种由多种作物产生的多酚类天然化合物。目前，白藜芦醇被认为是一种多靶点抗癌药物，具有多种活性，包括通过抑制血管生成和减少许多癌症模型中的侵袭和转移因子来阻止恶性细胞增殖的能力。然而，介导白藜芦醇对淋巴瘤细胞特异性作用的分子机制尚不清楚。为了解决这个问题，我们用白藜芦醇处理伯基特淋巴瘤细胞系 Ramos，并评估细胞存活和基因表达。我们的结果表明，白藜芦醇对 Ramos 细胞表现出显著的抗增殖和促凋亡活性，诱导 DNA 损伤反应、DNA 修复，并调节调节凋亡过程及其增殖活性的几个基因的表达。
