来自糙叶花椒（Pierre）Cheek 和 T. Heller（芸香科）的抗菌呋喃喹啉生物碱。
Antimicrobial Furoquinoline Alkaloids from Vepris lecomteana (Pierre) Cheek & T. Heller (Rutaceae).
机构信息
Department of Chemistry, University of Douala, Faculty of Sciences, 24157 Douala, Cameroon.
Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany.
出版信息
Molecules. 2017 Dec 21;23(1):13. doi: 10.3390/molecules23010013.
Three new prenylated furoquinoline alkaloids named lecomtequinoline A (), B (), and C (), together with the known compounds anhydroevoxine (), evoxine (), dictamnine (), methylflindersine (), evoxanthine (), hesperidin, lupeol, -sitosterol, stigmasterol, -sitosterol-3---d-glucopyranoside, stearic acid, and myristyl alcohol, were isolated by bioassay-guided fractionation of the methanolic extracts of leaves and stem of . The structures of compounds were determined by spectroscopic methods (NMR, MS, UV, and IR) and by comparison with previously reported data. Crude extracts of leaves and stem displayed high antimicrobial activity, with Minimum Inhibitory Concentration (MIC) (values of 10.1-16.5 and 10.2-20.5 µg/mL, respectively, against , , , , and , while compounds - showed values ranging from 11.1 to 18.7 µg/mL or were inactive, suggesting synergistic effect. The extracts may find application in crude drug preparations in Western Africa where is endemic, subject to negative toxicity results in vivo
从 Lecomtea chevalieri 的叶和茎的甲醇提取物中，通过生物测定指导的分步分离，得到了三个新的prenylated furoquinoline 生物碱命名为 lecomtequinoline A ()、B () 和 C ()，以及已知化合物 anhydroevoxine ()、evoxine ()、dictamnine ()、methylflindersine ()、evoxanthine ()、hesperidin、羽扇豆醇、β-谷甾醇、豆甾醇、β-谷甾醇-3---d-吡喃葡萄糖苷、硬脂酸和肉豆蔻醇。通过光谱方法 (NMR、MS、UV 和 IR) 和与以前报道的数据进行比较，确定了化合物的结构。叶和茎的粗提取物表现出很强的抗菌活性，对 、 、 、 、 和 的最小抑菌浓度 (MIC) 值分别为 10.1-16.5 和 10.2-20.5 μg/mL，而化合物 - 的值在 11.1 到 18.7 μg/mL 之间或无活性，表明存在协同作用。这些提取物可能在西非的粗药制剂中找到应用，因为那里是 Lecomtea chevalieri 的流行地区，需要进行体内毒性的阴性结果。
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