强大的成纤维细胞及其在硬皮病研究中的作用。
The mighty fibroblast and its utility in scleroderma research.
作者信息
Garrett Sara M, Baker Frost DeAnna, Feghali-Bostwick Carol
机构信息
Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charlestion, SC - USA.
出版信息
J Scleroderma Relat Disord. 2017 May-Aug;2(2):69-134. doi: 10.5301/jsrd.5000240. Epub 2017 May 19.
Abstract
Fibroblasts are the effector cells of fibrosis characteristic of systemic sclerosis (SSc, scleroderma) and other fibrosing conditions. The excess production of extracellular matrix (ECM) proteins is the hallmark of fibrosis in different organs, such as skin and lung. Experiments designed to assess the pro-fibrotic capacity of factors, their signaling pathways, and potential inhibitors of their effects that are conducted in fibroblasts have paved the way for planning clinical trials in SSc. As such, fibroblasts have proven to be valuable tools in the search for effective anti-fibrotic therapies for fibrosis. Herein we highlight the characteristics of fibroblasts, their role in the etiology of fibrosis, utility in experimental assays, and contribution to drug development and clinical trials in SSc.
摘要
成纤维细胞是系统性硬化症（SSc，硬皮病）和其他纤维化疾病所特有的纤维化效应细胞。细胞外基质（ECM）蛋白的过度产生是不同器官（如皮肤和肺）纤维化的标志。在成纤维细胞中进行的旨在评估各种因素的促纤维化能力、其信号通路以及其效应的潜在抑制剂的实验，为系统性硬化症的临床试验规划铺平了道路。因此，成纤维细胞已被证明是寻找有效的抗纤维化疗法治疗纤维化的宝贵工具。在此，我们重点介绍成纤维细胞的特征、它们在纤维化病因学中的作用、在实验分析中的用途以及对系统性硬化症药物开发和临床试验的贡献。
相似文献
1
The mighty fibroblast and its utility in scleroderma research.强大的成纤维细胞及其在硬皮病研究中的作用。
J Scleroderma Relat Disord. 2017 May-Aug;2(2):69-134. doi: 10.5301/jsrd.5000240. Epub 2017 May 19.
2
Scleroderma, fibroblasts, signaling, and excessive extracellular matrix.硬皮病、成纤维细胞、信号传导与过量细胞外基质
Curr Rheumatol Rep. 2005 Apr;7(2):156-62. doi: 10.1007/s11926-005-0069-9.
3
Tenascin-C in fibrosis in multiple organs: Translational implications.细胞外基质蛋白 tenascin-C 在多器官纤维化中的作用：转化医学意义。
Semin Cell Dev Biol. 2022 Aug;128:130-136. doi: 10.1016/j.semcdb.2022.03.019. Epub 2022 Apr 8.
4
Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signaling.骨膜蛋白通过调节 TGF-β 信号诱导人皮肤成纤维细胞的促纤维化表型。
J Dermatol Sci. 2018 May;90(2):199-208. doi: 10.1016/j.jdermsci.2018.02.001. Epub 2018 Feb 6.
5
IGFBP-5 Promotes Fibrosis via Increasing Its Own Expression and That of Other Pro-fibrotic Mediators.胰岛素样生长因子结合蛋白5通过增加自身及其他促纤维化介质的表达来促进纤维化。
Front Endocrinol (Lausanne). 2018 Oct 15;9:601. doi: 10.3389/fendo.2018.00601. eCollection 2018.
6
Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis.Netrin-1 调控去细胞化纤维化硬皮病肺微环境中纤维母细胞的积累和博来霉素诱导的肺纤维化。
Arthritis Rheumatol. 2016 May;68(5):1251-61. doi: 10.1002/art.39575.
7
The role of extracellular matrix components in angiogenesis and fibrosis: Possible implication for Systemic Sclerosis.细胞外基质成分在血管生成和纤维化中的作用：对系统性硬化症的潜在影响。
Mod Rheumatol. 2018 Nov;28(6):922-932. doi: 10.1080/14397595.2018.1431004. Epub 2018 Feb 15.
8
Scleroderma keratinocytes promote fibroblast activation independent of transforming growth factor beta.硬皮病角质形成细胞可促进成纤维细胞活化，且不依赖于转化生长因子β 。
Rheumatology (Oxford). 2017 Nov 1;56(11):1970-1981. doi: 10.1093/rheumatology/kex280.
9
Regulation of connective tissue synthesis in systemic sclerosis.系统性硬化症中结缔组织合成的调节
Int Rev Immunol. 1995;12(2-4):187-99. doi: 10.3109/08830189509056712.
10
Deciphering the pro-fibrotic phenotype of fibroblasts in systemic sclerosis.解析系统性硬化症中纤维母细胞的促纤维化表型。
Exp Dermatol. 2014 Feb;23(2):99-100. doi: 10.1111/exd.12237.
引用本文的文献
1
Distinct cAMP Regulation in Scleroderma Lung and Skin Myofibroblasts Governs Their Dedifferentiation via p38α Inhibition.硬皮病肺和皮肤肌成纤维细胞中不同的cAMP调节通过抑制p38α控制其去分化。
FASEB J. 2025 Jun 30;39(12):e70762. doi: 10.1096/fj.202500694RR.
2
Distinct cAMP regulation in scleroderma lung and skin myofibroblasts governs their dedifferentiation via p38α inhibition.硬皮病肺和皮肤肌成纤维细胞中不同的cAMP调节通过抑制p38α来控制它们的去分化。
bioRxiv. 2025 Mar 1:2025.02.26.640163. doi: 10.1101/2025.02.26.640163.
3
Widespread mutagenesis and chromosomal instability shape somatic genomes in systemic sclerosis.系统性硬化症中广泛的突变和染色体不稳定性塑造了体细胞基因组。
Nat Commun. 2024 Oct 15;15(1):8889. doi: 10.1038/s41467-024-53332-z.
4
Antioxidant, Antiinflammation, and Antifibrotic Activity of Ciplukan ( L). Extract.刺蒴麻提取物的抗氧化、抗炎和抗纤维化活性。
J Inflamm Res. 2024 Sep 10;17:6297-6306. doi: 10.2147/JIR.S470318. eCollection 2024.
5
in fibrosis treatment: a comprehensive review.纤维化治疗：全面综述
Front Pharmacol. 2024 Jul 30;15:1442181. doi: 10.3389/fphar.2024.1442181. eCollection 2024.
6
Transcriptomic characterization of lung pericytes in systemic sclerosis-associated pulmonary fibrosis.系统性硬化症相关肺纤维化中肺周细胞的转录组学特征
iScience. 2024 May 17;27(6):110010. doi: 10.1016/j.isci.2024.110010. eCollection 2024 Jun 21.
7
IGF-II regulates lysyl oxidase propeptide and mediates its effects in part via basic helix-loop-helix E40.IGF-II 调节赖氨酰氧化酶前肽，并通过基本螺旋-环-螺旋 E40 部分介导其作用。
Matrix Biol. 2024 Sep;132:24-33. doi: 10.1016/j.matbio.2024.06.002. Epub 2024 Jun 7.
8
The Crosstalk between N-Formyl Peptide Receptors and uPAR in Systemic Sclerosis: Molecular Mechanisms, Pathogenetic Role and Therapeutic Opportunities.N-甲酰肽受体与 uPAR 在系统性硬化症中的串扰：分子机制、发病作用和治疗机会。
Int J Mol Sci. 2024 Mar 9;25(6):3156. doi: 10.3390/ijms25063156.
9
Fibroblast Subpopulations in Systemic Sclerosis: Functional Implications of Individual Subpopulations and Correlations with Clinical Features.系统性硬化症中的成纤维细胞亚群：各亚群的功能意义及其与临床特征的相关性。
J Invest Dermatol. 2024 Jun;144(6):1251-1261.e13. doi: 10.1016/j.jid.2023.09.288. Epub 2023 Dec 24.
10
Lymphatic Endothelial-to-Myofibroblast Transition: A Potential New Mechanism Underlying Skin Fibrosis in Systemic Sclerosis.淋巴内皮细胞向肌成纤维细胞转化：系统性硬化症皮肤纤维化的潜在新机制。
Cells. 2023 Sep 1;12(17):2195. doi: 10.3390/cells12172195.
本文引用的文献
1
Biological characters of human dermal fibroblasts derived from foreskin of male infertile patients.来自男性不育患者包皮的人皮肤成纤维细胞的生物学特性。
Tissue Cell. 2017 Feb;49(1):56-63. doi: 10.1016/j.tice.2016.12.003. Epub 2016 Dec 8.
2
Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.霉酚酸酯与口服环磷酰胺治疗硬皮病相关间质性肺病（SLS II）：一项随机对照、双盲、平行组试验。
Lancet Respir Med. 2016 Sep;4(9):708-719. doi: 10.1016/S2213-2600(16)30152-7. Epub 2016 Jul 25.
3
Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial.托西珠单抗皮下注射治疗系统性硬化症成人患者的安全性和有效性（faSScinate）：一项 2 期、随机、对照试验。
Lancet. 2016 Jun 25;387(10038):2630-2640. doi: 10.1016/S0140-6736(16)00232-4. Epub 2016 May 5.
4
The Antifibrotic Effect of α2AP Neutralization in Systemic Sclerosis Dermal Fibroblasts and Mouse Models of Systemic Sclerosis.α2AP 中和在系统性硬化症皮肤成纤维细胞和系统性硬化症小鼠模型中的抗纤维化作用。
J Invest Dermatol. 2016 Apr;136(4):762-769. doi: 10.1016/j.jid.2015.12.028. Epub 2015 Dec 29.
5
The myofibroblast, a key cell in normal and pathological tissue repair.肌成纤维细胞是正常和病理组织修复中的关键细胞。
Cell Mol Life Sci. 2016 Mar;73(6):1145-57. doi: 10.1007/s00018-015-2110-0. Epub 2015 Dec 17.
6
Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor.信号素4A通过PlexinD1受体激活Akt来增强肺纤维化。
J Biosci. 2015 Dec;40(5):855-62. doi: 10.1007/s12038-015-9566-9.
7
Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway.达沙替尼通过Src-SRF途径抑制转化生长因子β诱导的肌成纤维细胞分化。
Eur J Pharmacol. 2015 Dec 15;769:134-42. doi: 10.1016/j.ejphar.2015.11.008. Epub 2015 Nov 6.
8
An endostatin-derived peptide orally exerts anti-fibrotic activity in a murine pulmonary fibrosis model.一种源自内皮抑素的肽在小鼠肺纤维化模型中具有抗纤维化活性。
Int Immunopharmacol. 2015 Oct;28(2):1102-5. doi: 10.1016/j.intimp.2015.07.039. Epub 2015 Aug 24.
9
Myofibroblasts.肌成纤维细胞
Exp Eye Res. 2016 Jan;142:56-70. doi: 10.1016/j.exer.2015.07.009. Epub 2015 Jul 17.
10
Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis.尼达尼布抑制成纤维细胞活化，并改善全身性硬皮病的临床前模型中的纤维化。
Ann Rheum Dis. 2016 May;75(5):883-90. doi: 10.1136/annrheumdis-2014-207109. Epub 2015 Apr 9.
Zotero 插件