Maxillofacial Unit, Halland Hospital, 30185, Halmstad, Sweden.
Blekinge Institute of Technology, Karlskrona, Sweden.
Clin Oral Investig. 2018 Jun;22(5):2103-2109. doi: 10.1007/s00784-017-2307-8. Epub 2017 Dec 21.
This study aims to evaluate the potential association between periodontitis, the number of teeth and cognitive functions in a cohort of older adults in Sweden.
In total, 775 individuals from 60 to 99 years of age were selected for the study. A clinical and radiographic examination was performed. The number of teeth and prevalence of periodontal pockets and bone loss was calculated and categorised. Cognitive functions were assessed using the Mini-Mental State Examination (MMSE) and clock test. The education level was obtained from a questionnaire. Data were analysed using chi-square tests and multivariate logistic regression.
Age and gender were associated with the prevalence of bone loss. Age and education were associated with lower number of teeth. Gender was also associated with the presence of pockets. The multivariate logistic regression analysis demonstrated a statistically significant association between prevalence of bone loss, the number of teeth and the outcome on MMSE test. This association remained even after adjustment for age, education and gender. Tooth loss was also associated with lower outcome on clock test. Presence of periodontal pockets ≥ 5 mm was not associated with cognitive test outcome.
A history of periodontitis and tooth loss may be of importance for cognitive functions among older adults.
Diseases with and inflammatory profile may have an impact on cognitive decline.
本研究旨在评估瑞典一组老年人的牙周炎、牙齿数量与认知功能之间的潜在关联。
共选取 775 名年龄在 60 至 99 岁的个体进行研究。进行了临床和影像学检查。计算和分类了牙齿数量以及牙周袋和骨丧失的患病率。使用简易精神状态检查（MMSE）和时钟测验评估认知功能。教育水平通过问卷获得。使用卡方检验和多变量逻辑回归进行数据分析。
年龄和性别与骨丧失的患病率相关。年龄和教育程度与牙齿数量减少有关。性别也与口袋的存在有关。多变量逻辑回归分析表明，骨丧失、牙齿数量和 MMSE 测试结果之间存在统计学显著关联。即使在调整了年龄、教育和性别后，这种关联仍然存在。牙齿缺失也与时钟测试的较低结果相关。牙周袋≥5mm 的存在与认知测试结果无关。
牙周炎和牙齿缺失的病史可能对老年人的认知功能有重要影响。
具有炎症特征的疾病可能对认知能力下降有影响。
