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低水平激光照射处理后的小鼠脂肪干细胞分泌的外泌体减少了低氧诱导的骨细胞凋亡。

Exosomes secreted by mice adipose-derived stem cells after low-level laser irradiation treatment reduce apoptosis of osteocyte induced by hypoxia.

机构信息

Laser Medical Center, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Technology, Yunnan, China.

出版信息

Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5562-5570. doi: 10.26355/eurrev_201712_13993.

Abstract

OBJECTIVE

Kienböck's disease is a commonly seen posttraumatic avascular necrosis characterized by avascular necrosis of the lunate bone of the wrist which involves the dominant hand. In our study, we aimed to present midterm outcomes of 12 cases treated with radial metaphyseal core decompression.

PATIENTS AND METHODS

In our clinic, 12 patients who applied to our outpatient clinic with intractable pain despite at least six weeks of conservative treatment were previously diagnosed and evaluated as Kienböck's disease between the years 2006 and 2014. Patients at early stage received radial metaphyseal core decompression.

RESULTS

The patients were evaluated as postoperative grip strength, flexion-extension gap, ulnar-radial deviation gap, VAS, Quick DASH and MAYO wrist scoring and patient satisfaction.

CONCLUSIONS

We determined that interventions performed for Kienböck's disease cannot halt radiological progression. We are of the opinion that radial metaphyseal core decompression, aiming at increasing blood perfusion, improve early diagnosis and treatment of Kienböck's disease, increasing the patient satisfaction.

摘要

目的

月骨缺血性坏死是一种常见的创伤后缺血性坏死,以腕部舟状骨缺血性坏死为特征,且常累及优势手。在本研究中,我们旨在报告 12 例采用桡骨骨干骺端髓芯减压治疗的中期结果。

患者和方法

2006 年至 2014 年间,我们的诊所对 12 例经至少 6 周保守治疗后仍有顽固性疼痛的患者进行了评估,这些患者之前被诊断为月骨缺血性坏死。早期患者接受了桡骨骨干骺端髓芯减压治疗。

结果

术后对患者的握力、屈伸间隙、尺桡侧偏间隙、VAS、QuickDASH 和 Mayo 腕关节评分以及患者满意度进行了评估。

结论

我们发现,针对月骨缺血性坏死的干预措施并不能阻止影像学进展。我们认为,桡骨骨干骺端髓芯减压术旨在增加血液灌注,提高月骨缺血性坏死的早期诊断和治疗水平,增加患者满意度。

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