Fagan J M, Tischler M E
Department of Biochemistry, University of Arizona, Tucson 85724.
Life Sci. 1989;44(10):677-81. doi: 10.1016/0024-3205(89)90473-6.
Isolated soleus muscle deprived of oxygen produces more lactate and alanine than oxygen-supplied muscle. Oxygenated muscle synthesized glutamine, while anoxic muscle used this amino acid. Oxygen deprivation decreased adenine nucleotides leading to the efflux of nucleosides. Protein synthesis and degradation responded differently to anoxia. Synthesis almost completely ceased, while proteolysis increased. Therefore, protein degradation in soleus muscle is enhanced when energy supplies and oxygen tension are low.
与供应氧气的肌肉相比，缺氧的离体比目鱼肌产生更多的乳酸和丙氨酸。有氧肌肉合成谷氨酰胺，而无氧肌肉则利用这种氨基酸。缺氧会降低腺嘌呤核苷酸，导致核苷外流。蛋白质合成和降解对缺氧的反应不同。合成几乎完全停止，而蛋白水解增加。因此，当能量供应和氧张力较低时，比目鱼肌中的蛋白质降解会增强。
