Acmella oleracea（L.）R.K. Jansen 花的水乙醇提取物对 Wistar 雌性大鼠生殖性能的影响：一种来自亚马逊的受欢迎的女性催情剂。
Action of the hydroethanolic extract of the flowers of Acmella oleracea (L.) R.K. Jansen on the reproductive performance of Wistar females rats: A popular female aphrodisiac from the Amazon.
机构信息
Laboratório de Pesquisa em Fármacos, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rod. Juscelino Kubitscheck, km 02, S/N, Macapá, AP 68903-419, Brazil; Programa de Pós-graduação em Ciências Farmacêuticas, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rod. Juscelino Kubitscheck, KM 02, S/N, Macapá, AP 68903-419, Brazil; Laboratório de Toxicologia Reprodutiva, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rod. Juscelino Kubitscheck, KM 02, S/N, Macapá, AP 68903-419, Brazil.
Programa de Pós-graduação em Ciências da Saúde, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Rod. Juscelino Kubitscheck, KM 02, S/N, Macapá, AP 68903-419, Brazil.
出版信息
J Ethnopharmacol. 2018 Mar 25;214:301-308. doi: 10.1016/j.jep.2017.12.024. Epub 2017 Dec 20.
ETHNOPHARMACOLOGICAL RELEVANCE
The species Acmella oleracea (L.) R.K. Jansen (Asteraceae), popularly known as jambú, is marketed in fairs as a female aphrodisiac and has several pharmacological activities already confirmed, among them the sexual stimulant action. The objective of this study was to evaluate the effects of the oral administration of the hydroethanolic extract of A. oleracea flowers (EHAo) on wistar rats during the pre-mating, mating, and pre-implantation period.
MATERIAL AND METHODS
During the treatment period, measurements of feed intake, water intake, weight, estrous cycle, behavior, reproductive parameters, biochemical parameters, hematological parameters, and histopathology of ovaries were performed daily.
RESULTS
In the gas chromatography analysis - mass spectrometry characterization, the compound (2E, 6Z, 8E) -N-isobutyldeca-2,6,8-trienamide (spilanthol) was detected as the majority compound at the 84% concentration. In the conditions of this study, EHAo did not cause maternal toxicity. However, in the estrous cycle, the frequency of the Proestrous (P) and Estrous (E) phase was significantly increased with the doses of 88.91 and 444.57mg/kg of the EHAo in relation to the control. On the other hand, the metaestrous (M) and diestrous (D) phases showed a significant reduction in their frequency in the groups treated with EHAo. Water intake increased significantly (p < 0.01), as well as the triglyceride levels, the total cholesterol and fractions (p < 0.05), and the percentage of neutrophils (p < 0.05).
CONCLUSION
It is concluded, therefore, that the treatment with EHAo, which is one of the forms popularly used, is safe in the concentrations and time of treatment studied as it is able to influence the estrous cycle without altering folliculogenesis and fertility.
民族药理学相关性
Acmella oleracea（L.）R.K. Jansen（菊科），俗称 jambú，在集市上作为女性壮阳药出售，并且已经证实了多种药理学作用，其中包括性刺激作用。本研究的目的是评估口服 A. oleracea 花的水醇提取物（EHAo）在交配前、交配期间和着床前对 Wistar 大鼠的影响。
材料和方法
在治疗期间，每天测量饲料摄入量、水摄入量、体重、发情周期、行为、繁殖参数、生化参数、血液学参数和卵巢组织病理学。
结果
在气相色谱分析-质谱特征分析中，检测到（2E，6Z，8E）-N-异丁基癸-2,6,8-三烯酰胺（spilanthol）作为主要化合物，浓度为 84%。在本研究条件下，EHAo 没有引起母体毒性。然而，在发情周期中，与对照组相比，EHAo 的 88.91 和 444.57mg/kg 剂量显著增加了发情前期（P）和发情期（E）阶段的频率。另一方面，发情后期（M）和间情期（D）阶段的频率显著降低。水摄入量显著增加（p<0.01），甘油三酯水平、总胆固醇和各部分（p<0.05）以及中性粒细胞百分比（p<0.05）也增加。
结论
因此，治疗浓度和治疗时间范围内的 EHAo 治疗是安全的，因为它能够影响发情周期而不改变卵泡发生和生育能力。
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