Shuwen Han, Qing Zhou, Yan Zheng, Xi Yang
Department of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
Department of Critical Care Medicine, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
Gene. 2018 Mar 1;645:157-162. doi: 10.1016/j.gene.2017.12.036. Epub 2017 Dec 19.
Colorectal cancer is one of the most common malignant tumours. Competitive endogenous RNA (ceRNA) networks have been hypothesized, in which various RNAs regulate each other's expression using microRNA response elements (MREs). Recent evidence has highlighted the crucial regulatory roles of ceRNA networks in colorectal cancer. In this review, we summarize the present research methods as well as the currently known ceRNA competitors and targets in colorectal cancer. In addition, we discuss the significance of ceRNA and shortcomings of current studies of colorectal cancer.
结直肠癌是最常见的恶性肿瘤之一。竞争性内源RNA（ceRNA）网络已被提出，在该网络中，各种RNA利用微小RNA反应元件（MRE）相互调节表达。最近的证据突出了ceRNA网络在结直肠癌中的关键调节作用。在本综述中，我们总结了结直肠癌目前的研究方法以及目前已知的ceRNA竞争物和靶点。此外，我们还讨论了ceRNA的意义以及结直肠癌当前研究的不足之处。
