一项北美的前瞻性生育队列研究：大麻使用与生育力。

Marijuana use and fecundability in a North American preconception cohort study.

机构信息

Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

RTI International, Research Triangle Park, Durham, North Carolina, USA.

出版信息

J Epidemiol Community Health. 2018 Mar;72(3):208-215. doi: 10.1136/jech-2017-209755. Epub 2017 Dec 22.

DOI:10.1136/jech-2017-209755

PMID:29273628

Abstract

BACKGROUND

The influence of marijuana use on human fertility has not been well studied. We evaluated the association between female and male use of marijuana and fecundability in Pregnancy Study Online, a prospective cohort of North American couples.

METHODS

Female participants completed a baseline questionnaire on which they reported lifestyle and behavioural factors, including frequency of marijuana use within the previous 2 months. Male partners completed an optional baseline questionnaire on similar factors, including marijuana use. Women completed follow-up questionnaires every 8 weeks for 12 months or until pregnancy, initiation of fertility treatment or loss to follow-up, whichever came first. The analysis was restricted to 4194 women (1125 couples) with ≤6 cycles of pregnancy attempt time at study enrolment (2013-2017). Fecundability ratios (FR) and 95% CIs were estimated using proportional probabilities regression models, with adjustment for potential confounders.

RESULTS

Men (14.2%) were more likely than women (11.6%) to be marijuana users. FRs for female marijuana use <1 and ≥1 time/week relative to non-use were 0.99 (95% CI 0.85 to 1.16) and 0.98 (95% CI 0.80 to 1.20), respectively. FRs for male marijuana use <1 and ≥1 time/week relative to non-use were 0.87 (95% CI 0.66 to 1.15) and 1.24 (95% CI 0.90 to 1.70), respectively. Associations for frequent marijuana use (≥1 time/week) were attenuated among non-smoking men (FR=1.21, 95% CI 0.84 to 1.74), but stronger among men reporting intercourse ≥4 times/week (FR=1.35, 95% CI 0.72 to 2.53).

CONCLUSIONS

In this preconception cohort study, there was little overall association between female or male marijuana use and fecundability.

摘要

背景

大麻使用对人类生育力的影响尚未得到充分研究。我们评估了女性和男性使用大麻与 Pregnancy Study Online 中北美夫妇前瞻性队列的生育能力之间的关联，该研究是一项针对生育能力的前瞻性队列研究。

方法

女性参与者完成了一份关于生活方式和行为因素的基线问卷，包括过去 2 个月内大麻使用的频率。男性伴侣完成了一份类似因素的可选基线问卷，包括大麻使用情况。女性每 8 周完成一次随访问卷，持续 12 个月或直到怀孕、开始生育治疗或失访，以先到者为准。分析仅限于研究入组时（2013-2017 年）≤6 个周期妊娠尝试时间的 4194 名女性（1125 对夫妇）。使用比例概率回归模型估计生育率比（FR）和 95%置信区间（CI），并调整潜在混杂因素。

结果

男性（14.2%）比女性（11.6%）更有可能使用大麻。与不使用大麻相比，女性每周使用大麻<1 次和≥1 次的 FR 分别为 0.99（95%CI 0.85-1.16）和 0.98（95%CI 0.80-1.20）。与不使用大麻相比，男性每周使用大麻<1 次和≥1 次的 FR 分别为 0.87（95%CI 0.66-1.15）和 1.24（95%CI 0.90-1.70）。不吸烟男性中频繁使用大麻（≥1 次/周）的关联减弱（FR=1.21，95%CI 0.84-1.74），但报告每周性交≥4 次的男性中关联更强（FR=1.35，95%CI 0.72-2.53）。