Berger J R, Sheremata W A, Resnick L, Atherton S, Fletcher M A, Norenberg M
Department of Neurology, University of Miami School of Medicine, FL.
Neurology. 1989 Mar;39(3):324-9. doi: 10.1212/wnl.39.3.324.
We describe seven men with a neurologic disease clinically indistinguishable from multiple sclerosis occurring in association with seropositivity for the human immunodeficiency virus, type 1 (HIV-1). Histopathology of the CNS obtained in three patients (2 by brain biopsy, 1 at autopsy) was consistent with MS. The neurologic symptoms preceded the onset of clinically evident immunosuppression in all patients. In three men, HIV-1 seropositivity was demonstrated concomitantly or within 3 months of the onset of their neurologic disease. In the others, features of MS preceded the demonstration of HIV-1 seropositivity by 41 months, 59 months, 11 years, and 18 years, respectively. Despite the superimposition of varying degrees of cellular immunodeficiency associated with HIV-1 infection, six of these men continued to experience relapsing neurologic symptoms.
我们描述了7名患有神经系统疾病的男性，其临床表现与多发性硬化症无法区分，且与1型人类免疫缺陷病毒（HIV-1）血清阳性有关。3例患者（2例经脑活检，1例尸检）的中枢神经系统组织病理学与多发性硬化症相符。所有患者的神经症状均先于临床明显免疫抑制的出现。在3名男性中，HIV-1血清阳性在其神经疾病发作时或发作后3个月内被证实。在其他患者中，多发性硬化症的特征分别比HIV-1血清阳性的出现早41个月、59个月、11年和18年。尽管叠加了与HIV-1感染相关的不同程度的细胞免疫缺陷，但其中6名男性仍持续出现复发性神经症状。
