University of Lyon, University of Lyon 1 Claude Bernard Lyon1, NeuroMyoGene Institute, CNRS UMR5310, INSERM U1217, 16 rue Raphael Dubois, F-69000 Lyon, France.
University of Lyon, University of Lyon 1 Claude Bernard Lyon1, NeuroMyoGene Institute, CNRS UMR5310, INSERM U1217, 16 rue Raphael Dubois, F-69000 Lyon, France.
Semin Cell Dev Biol. 2019 Jan;85:3-12. doi: 10.1016/j.semcdb.2017.12.010. Epub 2018 Jan 3.
The navigation of commissural axons in the developing spinal cord has attracted multiple studies over the years. Many important concepts emerged from these studies which have enlighten the general mechanisms of axon guidance. The navigation of commissural axons is regulated by a series of cellular territories which provides the diverse guidance information necessary to ensure the successive steps of their pathfinding towards, across, and away from the ventral midline. In this review, we discuss how repulsive forces, by propelling, channelling, and confining commissural axon navigation, bring key contributions to the formation of this neuronal projection.
多年来，发育中脊髓连合轴突的导航吸引了多项研究。这些研究提出了许多重要概念，阐明了轴突导向的一般机制。连合轴突的导航受一系列细胞区域的调节，这些区域提供了必要的多样化导向信息，以确保它们在向腹中线前进、穿过和离开腹中线的连续步骤中的寻路。在这篇综述中，我们讨论了排斥力如何通过推动、引导和限制连合轴突的导航，为这种神经元投射的形成做出关键贡献。
