Mohammadi Seyed-Farzad, Saeedi-Anari Ghasem, Ashrafi Elham, Mohammadi Seyed-Mehrdad, Farzadfar Farshad, Lashay Alireza, Hashemi Hassan
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Middle East Afr J Ophthalmol. 2017 Jul-Sep;24(3):148-155. doi: 10.4103/meajo.MEAJO_168_16.
The purpose of this study is to provide a pooled estimate of moderate-to-severe visual impairment (MSVI) and blindness in Iran for people 50 years and over and to identify the major causes through systematic review.
International (PubMed, ISI Web of Science, and Scopus) and national databases (Scientific Information Database, Barakat Knowledge Network System, Iran Databank of Ophthalmology Research, and Magiran) databases were searched. Following relevance assessment and critical appraisal, eight studies were included. A funnel plot was drawn to explore the stability for estimation. Single-variable meta-regression analysis was applied for heterogeneity assessment, and a random effect model was used (but no significant source for the observed heterogeneity was found).
Age-standardized pooled estimate of MSVI was 4.24% (95% confidence interval [CI]: 2.92-5.56); 3.98% (95% CI: 2.37-5.59) for men, and 4.08% (95% CI: 2.95-5.21) for women. Blindness (visual acuity <3/60) prevalence was 1.31% (95% CI: 1.23-1.39); 0.96% (95% CI: 0.89-1.03) for men, and 1.13% (95% CI: 1.06-1.20) for women. Causes of visual impairment (VI) were cataract (40.23%), amblyopia (12.03%), corneal opacity (9.63%), age-related macular degeneration (9.31%), diabetic retinopathy (4.94%), and glaucoma (3.67%).
VI prevalence in the 50 years and older population in Iran seems significantly better than the corresponding global estimates. A rough 60% rate of treatable VI was estimated, mostly attributable to unoperated cataract.
本研究旨在对伊朗50岁及以上人群中重度视力损害（MSVI）和失明情况进行汇总估计，并通过系统评价确定主要病因。
检索了国际数据库（PubMed、ISI科学网和Scopus）和国内数据库（科学信息数据库、巴拉卡特知识网络系统、伊朗眼科研究数据库和Magiran）。经过相关性评估和严格评价，纳入了八项研究。绘制漏斗图以探讨估计的稳定性。应用单变量meta回归分析进行异质性评估，并使用随机效应模型（但未发现观察到的异质性的显著来源）。
年龄标准化的MSVI汇总估计值为4.24%（95%置信区间[CI]：2.92 - 5.56）；男性为3.98%（95%CI：2.37 - 5.59），女性为4.08%（95%CI：2.95 - 5.21）。失明（视力<3/60）患病率为1.31%（95%CI：1.23 - 1.39）；男性为0.96%（95%CI：0.89 - 1.03），女性为1.13%（95%CI：1.06 - 1.20）。视力损害（VI）的病因包括白内障（40.23%）、弱视（12.03%）、角膜混浊（9.63%）、年龄相关性黄斑变性（9.31%）、糖尿病视网膜病变（4.94%）和青光眼（3.67%）。
伊朗50岁及以上人群的视力损害患病率似乎明显优于相应的全球估计值。估计约60%的可治疗视力损害病例，主要归因于未手术治疗的白内障。
