Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Shandong University, No. 324, Jingwu Road, Jinan, 250021, People's Republic of China.
Imaging and Nuclear Medicine, Shandong Provincial Qianfoshan Hospital, Jinan, 250021, People's Republic of China.
Jpn J Radiol. 2018 Mar;36(3):194-199. doi: 10.1007/s11604-017-0714-z. Epub 2017 Dec 26.
The aim of this study was to compare the gamma-amino butyric acid (GABA) levels in the left basal ganglia (BG) of patients with Parkinson's disease (PD) to those of healthy control (HC) volunteers using proton magnetic resonance spectroscopy (H MRS).
The GABA+ signal-the composite signal from GABA, macromolecules (MMs), and homocarnosine-was detected. GABA+ levels were examined in 21 PD patients and 15 age- and sex-matched HCs. 3T-H-MRS using the Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) sequence was performed in order to detect GABA+ levels in the left BG, and the spectra were processed using the Gannet software. Differences in GABA+ levels between the two groups were analyzed using independent t-test analysis.
The GABA+ levels were significantly lower (P < 0.001) in the left BG of the patients with PD (1.31 ± 0.21 i.u.) than in the left BG of the HCs (1.62 ± 0.26 i.u.).
The lower GABA+ levels in the left BG of the PD patients suggest that GABA plays an important role in the pathogenesis of PD. The reduced GABA+ levels in the PD patients may be associated with GABAergic dysfunction.
本研究旨在通过质子磁共振波谱（1 H MRS）比较帕金森病（PD）患者与健康对照（HC）志愿者左基底节（BG）中的γ-氨基丁酸（GABA）水平。
检测 GABA+信号-来自 GABA、大分子（MMs）和同型瓜氨酸的复合信号。检查了 21 名 PD 患者和 15 名年龄和性别匹配的 HC 中的 GABA+水平。使用 Mescher-Garwood 点分辨波谱（MEGA-PRESS）序列在 3T 进行 1 H MRS，以检测左 BG 中的 GABA+水平，并使用 Gannet 软件处理光谱。使用独立 t 检验分析两组之间 GABA+水平的差异。
PD 患者左 BG 的 GABA+水平明显低于 HC（1.31±0.21 i.u.比 1.62±0.26 i.u.，P<0.001）。
PD 患者左 BG 中的 GABA+水平较低表明 GABA 在 PD 的发病机制中起重要作用。PD 患者中 GABA+水平降低可能与 GABA 能功能障碍有关。
