Department of MR, Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong, P.R. China.
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P.R. China.
J Magn Reson Imaging. 2018 Jun;47(6):1610-1615. doi: 10.1002/jmri.25865. Epub 2017 Sep 27.
Parkinson's disease (PD) is divided into postural instability gait difficulty (PIGD) and tremor-dominant (TD) subtypes. Increasing evidence has suggested that the GABAergic neurotransmitter system is involved in the pathogenesis of PD.
To evaluate the differences of GABA levels between PD motor subtypes using MEscher-GArwood Point Resolved Spectroscopy (MEGA-PRESS).
COHORT.: SUBJECTS: PD patients were classified into PIGD (n = 13) and TD groups (n = 9); 16 age- and sex-matched healthy controls were also recruited. All subjects were right-handed.
All subjects underwent an magnetic resonance spectroscopy scan including MEGA-PRESS at 3.0T.
The detected GABA signal also contains signal from macromolecules (MM) and homocarnosine, so it is referred to as GABA+. GABA + levels and Creatine (Cr) levels were quantified in the left basal ganglia (BG) using Gannet 2.0 by Tao Gong.
Differences in GABA + levels between the three groups were analyzed using analysis of covariance. The relationship between GABA levels and a unified PD rating scale (UPDRS) was also analyzed.
GABA + levels were significantly lower in left BG regions of PD patients compared with healthy controls (P < 0.001). In PD patients, the GABA concentration was lower in the TD group than the PIGD group (P = 0.019). Cr levels in PIGD and TD were lower than controls (P = 0.020; P = 0.002). A significant negative correlation was found in PIGD between GABA levels and UPDRS (r = -0.572, P = 0.041), while no correlation was found in TD (r = -0.339, P = 0.372).
Low BG GABA levels in PD patients, and differences between PIGD/TD patients, suggest that GABAergic dysfunction may play an important role in the pathogenesis of Parkinson's disease.
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:1610-1615.
帕金森病（PD）分为姿势不稳步态困难（PIGD）和震颤为主（TD）两种亚型。越来越多的证据表明，GABA 能神经递质系统参与 PD 的发病机制。
使用 MEscher-GArwood 点分辨波谱（MEGA-PRESS）评估 PD 运动亚型之间 GABA 水平的差异。
队列研究。
PD 患者分为 PIGD 组（n=13）和 TD 组（n=9）；还招募了 16 名年龄和性别匹配的健康对照者。所有受试者均为右利手。
所有受试者均在 3.0T 磁共振波谱仪上进行 MEGA-PRESS 扫描。
检测到的 GABA 信号还包含大分子（MM）和同型瓜氨酸的信号，因此称为 GABA+。使用 Tao Gong 的 Gannet 2.0 在左侧基底节（BG）中定量检测 GABA+和肌酸（Cr）水平。
采用协方差分析比较三组间 GABA+水平的差异。还分析了 GABA 水平与统一帕金森病评定量表（UPDRS）之间的关系。
与健康对照组相比，PD 患者左侧 BG 区域的 GABA+水平显著降低（P<0.001）。在 PD 患者中，TD 组的 GABA 浓度低于 PIGD 组（P=0.019）。PIGD 和 TD 组的 Cr 水平低于对照组（P=0.020；P=0.002）。在 PIGD 中，GABA 水平与 UPDRS 之间存在显著负相关（r=-0.572，P=0.041），而在 TD 中无相关性（r=-0.339，P=0.372）。
PD 患者的 BG GABA 水平降低，以及 PIGD/TD 患者之间的差异表明，GABA 能功能障碍可能在帕金森病的发病机制中起重要作用。
1 技术功效：第 2 阶段 J. Magn. Reson. Imaging 2018;47:1610-1615.
