Department of Imaging and Nuclear Medicine, Shandong Medical Imaging Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.
Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
MAGMA. 2021 Oct;34(5):689-696. doi: 10.1007/s10334-021-00910-7. Epub 2021 Mar 20.
The dopaminergic pathology of Parkinson's disease (PD) impacts circuits involving GABAergic neurons, especially in the brainstem, where the disease manifests early. The aim of this study is to test the hypothesis that levels of gamma-aminobutyric acid (GABA) in the upper brainstem are reduced in patients with PD compared to healthy controls, using edited magnetic resonance spectroscopy (MRS of GABA +).
GABA + levels were examined in 18 PD patients and 18 age- and sex-matched healthy controls (HCs). GABA + -edited MRS was performed in 7.5-ml voxels in the upper brainstem, and the spectra were processed using the Gannet software. Differences in GABA + levels between the two groups were analyzed using independent t test analysis.
GABA + levels were significantly lower (p < 0.05) in the upper brainstem of the patients with PD (4.57 ± 0.94 mM) than the HCs (5.89 ± 1.16 mM).
The lower GABA + levels in the upper brainstem of the PD patients suggest that a GABAergic deficit in the brainstem may contribute to the pathology in PD.
帕金森病（PD）的多巴胺病理影响涉及 GABA 能神经元的回路，尤其是在疾病早期表现的脑干中。本研究旨在通过编辑磁共振波谱（GABA+的 MRS）来检验 PD 患者上脑干中的γ-氨基丁酸（GABA）水平低于健康对照组的假设。
我们检查了 18 名 PD 患者和 18 名年龄和性别匹配的健康对照组（HCs）的 GABA+水平。使用 Gannet 软件对上脑干的 7.5 毫升体素进行 GABA+编辑 MRS，处理光谱。使用独立 t 检验分析两组之间 GABA+水平的差异。
PD 患者上脑干中的 GABA+水平明显低于健康对照组（4.57±0.94 mM 比 5.89±1.16 mM，p<0.05）。
PD 患者上脑干中较低的 GABA+水平提示脑干中的 GABA 能缺陷可能导致 PD 的病理学改变。
