Kelly Cambre N, Miller Andrew T, Hollister Scott J, Guldberg Robert E, Gall Ken
Department of Mechanical Engineering and Materials Science, Duke University, Box 90300 Hudson Hall, Durham, NC, 27708, USA.
Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 313 Ferst Drive, Room 2127, Atlanta, GA, 30332, USA.
Adv Healthc Mater. 2018 Apr;7(7):e1701095. doi: 10.1002/adhm.201701095. Epub 2017 Dec 27.
3D printing is now adopted for use in a variety of industries and functions. In biomedical engineering, 3D printing has prevailed over more traditional manufacturing methods in tissue engineering due to its high degree of control over both macro- and microarchitecture of porous tissue scaffolds. However, with the improved flexibility in design come new challenges in characterizing the structure-function relationships between various architectures and both mechanical and biological properties in an assortment of clinical applications. Presently, the field of tissue engineering lacks a comprehensive body of literature that is capable of drawing meaningful relationships between the designed structure and resulting function of 3D printed porous biomaterial scaffolds. This work first discusses the role of design on 3D printed porous scaffold function and then reviews characterization of these structure-function relationships for 3D printed synthetic metallic, polymeric, and ceramic biomaterials.
3D打印如今已被应用于各种行业和功能领域。在生物医学工程中，由于3D打印在多孔组织支架的宏观和微观结构控制方面具有高度精确性，因此在组织工程领域已胜过更为传统的制造方法。然而，随着设计灵活性的提高，在各种临床应用中，表征不同结构与机械性能和生物学性能之间的结构 - 功能关系面临新的挑战。目前，组织工程领域缺乏能够揭示3D打印多孔生物材料支架的设计结构与最终功能之间有意义关系的全面文献。这项工作首先讨论设计对3D打印多孔支架功能的作用，然后综述3D打印合成金属、聚合物和陶瓷生物材料的这些结构 - 功能关系的表征。
