Tissue Bioengineering, University of Bordeaux, Bordeaux, France.
Faculty of Dentistry, University of Bordeaux, Bordeaux, France.
J Biomed Mater Res B Appl Biomater. 2019 Nov;107(8):2579-2595. doi: 10.1002/jbm.b.34348. Epub 2019 Mar 8.
Applications in additive manufacturing technologies for bone tissue engineering applications requires the development of new biomaterials formulations. Different three-dimensional (3D) printing technologies can be used and polymers are commonly employed to fabricate 3D printed bone scaffolds. However, these materials used alone do not possess an effective osteopromotive potential for bone regeneration. A growing number of studies report the combination of polymers with minerals in order to improve their bioactivity. This review exposes the state-of-the-art of existing 3D printed composite biomaterials combining polymers and minerals for bone tissue engineering. Characterization techniques to assess scaffold properties are also discussed. Several parameters must be considered to fabricate a 3D printed material for bone repair (3D printing method, type of polymer/mineral combination and ratio) because all of them affect final properties of the material. Each polymer and mineral has its own advantages and drawbacks and numerous composites are described in the literature. Each component of these composite materials brings specific properties and their combination can improve the biological integration of the 3D printed scaffold. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2579-2595, 2019.
应用于骨组织工程应用的增材制造技术需要开发新的生物材料配方。可以使用不同的三维(3D)打印技术,并且通常使用聚合物来制造 3D 打印的骨支架。然而,这些单独使用的材料不具有有效的成骨促进潜力,用于骨再生。越来越多的研究报告称,聚合物与矿物质结合以提高其生物活性。本综述介绍了将聚合物与矿物质结合用于骨组织工程的现有 3D 打印复合生物材料的最新技术。还讨论了用于评估支架性能的表征技术。必须考虑许多参数来制造用于骨修复的 3D 打印材料(3D 打印方法、聚合物/矿物质组合的类型和比例),因为所有这些参数都影响材料的最终性能。每种聚合物和矿物质都有其自身的优点和缺点,并且在文献中描述了许多复合材料。这些复合材料的每个组件都具有特定的性能,它们的组合可以提高 3D 打印支架的生物整合性。© 2019 Wiley Periodicals,Inc. J Biomed Mater Res Part B:Appl Biomater 107B:2579-2595,2019。
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