Wijarnpreecha Karn, Jaruvongvanich Veeravich, Cheungpasitporn Wisit, Ungprasert Patompong
Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York.
Department of Internal Medicine, University of Hawaii, Honolulu, Hawaii.
Eur J Gastroenterol Hepatol. 2018 Apr;30(4):442-446. doi: 10.1097/MEG.0000000000001048.
BACKGROUND/OBJECTIVE: Recent epidemiologic studies have suggested that patients with celiac disease might be at an increased risk of schizophrenia. However, the data on this risk remain inconclusive. This meta-analysis was conducted with the aim to summarize all available evidence.
A literature search was carried out using MEDLINE and Embase database from inception to June 2017. Studies that compared the risk of schizophrenia among patients with celiac disease versus individuals without celiac disease were included. Pooled odds ratio and 95% confidence interval were calculated using a random-effect, generic inverse-variance method.
Of the 284 retrieved studies, four met our eligibility criteria and were included in the analysis. We found a higher risk of schizophrenia among patients with celiac disease compared with individuals without celiac disease with the pooled odds ratio of 2.03 (95% confidence interval: 1.45-2.86). The statistical heterogeneity of this study was insignificant (I=0%).
This systematic review and meta-analysis found a significantly higher risk of schizophrenia among patients with celiac disease.
背景/目的：近期的流行病学研究表明，乳糜泻患者患精神分裂症的风险可能会增加。然而，关于这一风险的数据仍无定论。进行这项荟萃分析的目的是总结所有现有证据。
使用MEDLINE和Embase数据库进行文献检索，检索时间从数据库建立至2017年6月。纳入比较乳糜泻患者与非乳糜泻患者精神分裂症风险的研究。采用随机效应、通用逆方差法计算合并比值比和95%置信区间。
在检索到的284项研究中，有4项符合我们的纳入标准并纳入分析。我们发现，与非乳糜泻患者相比，乳糜泻患者患精神分裂症的风险更高，合并比值比为2.03（95%置信区间：1.45 - 2.86）。本研究的统计学异质性不显著（I² = 0%）。
这项系统评价和荟萃分析发现，乳糜泻患者患精神分裂症的风险显著更高。
