Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China.
Fitoterapia. 2012 Apr;83(3):518-22. doi: 10.1016/j.fitote.2011.12.018. Epub 2011 Dec 30.
Three new halogenated sesquiterpenes, 10-bromo-7α,8α-expoxychamigr-1-en-3-ol (1), 10-bromo-β-chamigren-8-ol (2), and 10-bromo-3-chlorocupar-5-en-2-ol (3), one new C₁₂-acetogenin, desepilaurallene (7), one new naturally occurring sesquiterpene, 7-hydroxylaurene acetate (4), two known sesquiterpenes, allolaurinterol acetate (5) and laurene (6), and one known C₁₅-acetogenin, epilaurallene (8), were isolated from the marine red alga Laurencia okamurai collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 4, 5 exhibited potent antibacterial activity, and 1, 4, 5 were toxic to brine shrimp.
从中国荣成沿海采集的海洋红藻劳伦藻中分离得到三个新的卤代倍半萜，分别为 10-溴-7α,8α-环氧查尔酮-1-烯-3-醇（1）、10-溴-β-查尔酮-8-醇（2）和 10-溴-3-氯-古巴烯-2-醇（3）；一个新的 C₁₂-乙酰基醇，去表劳拉烯（7）；一个新的天然存在的倍半萜，7-羟基劳伦乙酸酯（4）；两个已知的倍半萜，乙酸阿洛劳醇（5）和劳烯（6）；以及一个已知的 C₁₅-乙酰基醇，表劳拉烯（8）。这些化合物的结构通过 1D、2D NMR 和质谱技术得到了明确的确定。生物测定结果表明，化合物 4 和 5 具有很强的抗菌活性，化合物 1、4 和 5 对卤虫有毒。
