Mangalampalli Bhanuramya, Dumala Naresh, Perumalla Venkata Rekhadevi, Grover Paramjit
Toxicology Unit, Pharmacology and Toxicology Department, CSIR - Indian Institute of Chemical Technology, Hyderabad, Telangana, 500007, India.
Academy of Scientific and Innovative Research, CSIR - Indian Institute of Chemical Technology, Hyderabad, Telangana, 500007, India.
Environ Toxicol. 2018 Apr;33(4):396-410. doi: 10.1002/tox.22526. Epub 2017 Dec 28.
Increased utilization and exposure levels of Magnesium oxide (MgO) nanoparticles (NPs) to humans and environment may raise unexpected consequences. The goal of this study was to evaluate the toxicological implications of MgO NPs and MPs after 28 day repeated oral administration in Wistar rats with three different doses (250, 500, and 1000 mg/kg). The MgO particles were characterised systematically in order to get more insights of the toxicological behaviour. MgO NPs induced significant DNA damage and aberrations in chromosomes. Moreover, hepatic enzymes released into the systemic circulation caused significant elevated levels of physiological enzymes in blood. NPs could interfere with proteins and enzymes and alter the redox balance in cell environment. Significant accumulation of Mg in all tissues and clearance via urine and faeces was noted in size dependent kinetics. Oral administration of MgO NPs altered the biochemical and genotoxic parameters in dose dependent and gender independent manner.
氧化镁（MgO）纳米颗粒（NPs）对人类和环境的利用率及暴露水平增加可能会引发意想不到的后果。本研究的目的是评估在Wistar大鼠中以三种不同剂量（250、500和1000 mg/kg）进行28天重复口服给药后，MgO NPs和 MPs的毒理学影响。对MgO颗粒进行了系统表征，以便更深入了解其毒理学行为。MgO NPs导致了显著的DNA损伤和染色体畸变。此外，释放到体循环中的肝酶导致血液中生理酶水平显著升高。NPs可能会干扰蛋白质和酶，并改变细胞环境中的氧化还原平衡。在所有组织中均观察到Mg的显著积累，并通过尿液和粪便以尺寸依赖性动力学进行清除。口服MgO NPs以剂量依赖性和性别无关的方式改变了生化和遗传毒性参数。
