Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagar, Mysuru, 570015, India.
Curr Drug Targets. 2018;19(10):1177-1190. doi: 10.2174/1389450119666171227205525.
Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported as one of the propitious bio-polymers for various drug delivery systems, as well as drug delivery vehicle.
This review is a summary of comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer.
SF has been reported as one of the propitious bio-polymers for various drug delivery systems, as well as drug delivery vehicle. SF is inestimable owing to its non-toxic and non-antigenic character, except for the firmness formation whilst being stored at lower temperature. Unlike other polymeric biomaterials, SF is regenerated in aqueous systems in defined temperature, pressure and pH, which is one of its major advantages in formulation. SF nanoparticles are also used to deliver proteins and peptides. Recently, SF has been used to deliver anti-cancer agents like paclitaxel, doxorubicin, floxuridine, and methotrexate, and including the natural product curcumin, has shown to elicit significant biological activity when compared to their conventional form. Interestingly, SF has shown to be a promising biomaterial for implantables and injectable drug delivery applications.
In the present review, we have summarized the physical and chemical properties, biocompatibility and non-immunogenic characters of SF and its applications in various drug delivery systems.
丝素纤维（SF）是一种从家蚕中提取的天然材料，具有出色的机械性能，已被广泛用作生物材料。SF 已被报道为各种药物输送系统以及药物输送载体的有利生物聚合物之一。
本综述总结了丝素纤维在各种药物输送系统中的综合应用，并通过对丝素纤维作为聚合物的明确评估，提出了当前的机遇和要求。
SF 已被报道为各种药物输送系统以及药物输送载体的有利生物聚合物之一。SF 具有无毒和非抗原性的特点，除了在低温下储存时形成的坚固性外。与其他聚合生物材料不同，SF 在定义的温度、压力和 pH 值下在水系统中再生，这是其在配方中的主要优势之一。SF 纳米颗粒也用于输送蛋白质和肽。最近，SF 已被用于输送紫杉醇、阿霉素、氟尿嘧啶和甲氨蝶呤等抗癌药物，以及天然产物姜黄素，与它们的常规形式相比，显示出显著的生物活性。有趣的是，SF 已被证明是一种有前途的可植入和可注射药物输送应用的生物材料。
在本综述中，我们总结了 SF 的物理化学性质、生物相容性和非免疫原性特征及其在各种药物输送系统中的应用。
