Su Xudong, Wei Li, Xu Zhenghao, Qin Leilei, Yang Jianye, Zou Yinshuang, Zhao Chen, Chen Li, Hu Ning
Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Laboratory of Orthopedics, Chongqing Medical University, Chongqing 400016, China.
Biomedicines. 2023 Aug 10;11(8):2244. doi: 10.3390/biomedicines11082244.
Osteoarthritis (OA) is a common joint disease characterized by cartilage damage and degeneration. Traditional treatments such as NSAIDs and joint replacement surgery only relieve pain and do not achieve complete cartilage regeneration. Silk fibroin (SF) biomaterials are novel materials that have been widely studied and applied to cartilage regeneration. By mimicking the fibrous structure and biological activity of collagen, SF biomaterials can promote the proliferation and differentiation of chondrocytes and contribute to the formation of new cartilage tissue. In addition, SF biomaterials have good biocompatibility and biodegradability and can be gradually absorbed and metabolized by the human body. Studies in recent years have shown that SF biomaterials have great potential in treating OA and show good clinical efficacy. Therefore, SF biomaterials are expected to be an effective treatment option for promoting cartilage regeneration and repair in patients with OA. This article provides an overview of the biological characteristics of SF, its role in bone and cartilage injuries, and its prospects in clinical applications to provide new perspectives and references for the field of bone and cartilage repair.
骨关节炎（OA）是一种常见的关节疾病，其特征为软骨损伤和退变。非甾体抗炎药（NSAIDs）和关节置换手术等传统治疗方法只能缓解疼痛，无法实现完全的软骨再生。丝素蛋白（SF）生物材料是一类已被广泛研究并应用于软骨再生的新型材料。通过模拟胶原蛋白的纤维结构和生物活性，SF生物材料可促进软骨细胞的增殖和分化，并有助于新软骨组织的形成。此外，SF生物材料具有良好的生物相容性和生物降解性，能够被人体逐渐吸收和代谢。近年来的研究表明，SF生物材料在治疗OA方面具有巨大潜力，并显示出良好的临床疗效。因此，SF生物材料有望成为促进OA患者软骨再生和修复的有效治疗选择。本文综述了SF的生物学特性、其在骨与软骨损伤中的作用以及其临床应用前景，为骨与软骨修复领域提供新的视角和参考。
