Kopaladze R A
Usp Fiziol Nauk. 2017 Jan-Mar;48(1):53-65.
Analysis of scientific works from the creation of an experimental model of diabetes before discovery insulin was done. Emphasized is the priority of the Russian pathologist L. W. Sobolew (1876-1919) in the discovery of the endocrine function of the pancreas in experimental animals - rabbits, dogs, cats. In 1923 Canadian scientists Banting and Macleod were awarded the Nobel prize for the discovery of insulin. However, the methods and the idea of Nobel laureates were the same that had been developed 20 years earlier by the Russian scientists. Currently, the incidence of diabetes and related pathologies of organs and systems are growing. The use of animals in experimental biology and medicine will continue for the foreseeable future. The benefits to science and medicine derived from the use of animals in research are undeniable, but this process inevitably increases the responsibility of researchers. It is required constant work on improvement of the experimental methods in order to minimize pain, stress, and the number of animals used in the experiment.
对胰岛素发现之前糖尿病实验模型创建的科学著作进行了分析。强调了俄罗斯病理学家L. W. 索博列夫（1876 - 1919）在发现实验动物（兔子、狗、猫）胰腺内分泌功能方面的优先权。1923年，加拿大科学家班廷和麦克劳德因发现胰岛素而获得诺贝尔奖。然而，诺贝尔奖获得者的方法和想法与20年前俄罗斯科学家所开发的相同。目前，糖尿病以及相关器官和系统疾病的发病率正在上升。在可预见的未来，实验生物学和医学中动物的使用仍将继续。在研究中使用动物给科学和医学带来的益处是不可否认的，但这一过程不可避免地增加了研究人员的责任。需要不断致力于改进实验方法，以尽量减少疼痛、压力以及实验中使用的动物数量。
