Ionescu-Tirgoviste C
Clinic of Diabetes, Institute N.C. Paulescu, Bucharest, Romania.
Arch Physiol Biochem. 1996 Dec;104(7):807-13. doi: 10.1076/apab.104.7.807.13106.
The most celebrated medical discovery of this century is comprised of two distinct stages: (1) that of fundamental research, i.e. the experimental demonstration of the presence in the pancreas of an antidiabetic hormone done by Paulescu and published on 31 August 1921 in the Archives Internationales de Physiologie; and (2) the clinical application of the discovery of insulin in the treatment of diabetes in man, the stage completed in 1922 by the Canadian group comprised of Collip, Macleod, Banting and Best.
（1）基础研究阶段，即保莱斯库所做的胰腺中存在抗糖尿病激素的实验证明，并于1921年8月31日发表在《国际生理学档案》上；（2）胰岛素发现应用于人类糖尿病治疗的临床阶段，该阶段于1922年由科利普、麦克劳德、班廷和贝斯特组成的加拿大团队完成。
