人工分子机器在纳米诊疗中的应用
Artificial Molecular Machines in Nanotheranostics.
机构信息
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health , Bethesda, Maryland 20892, United States.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University , Hangzhou 310027, P.R. China.
出版信息
ACS Nano. 2018 Jan 23;12(1):7-12. doi: 10.1021/acsnano.7b07851. Epub 2017 Dec 28.
Due to their dynamic nature and excellent stimuli-responsiveness resulting from noncovalent driving forces, artificial molecular machines (AMMs) show great promise in cancer theranostics. In this Perspective, we introduce the potential applications of AMMs in controlled drug delivery, bioorthogonal catalysis, imaging, and cell membrane permeabilization, with the goal of enhancing cancer diagnosis and therapy. We expect this preliminary discussion will garner multidisciplinary interest from scientists to advance AMMs and to expand their future clinical applications.
由于其动态特性和非共价驱动力带来的出色刺激响应性，人工分子机器（AMM）在癌症诊治中具有广阔的应用前景。在本观点中，我们介绍了 AMM 在控制药物输送、生物正交催化、成像和细胞膜通透性方面的潜在应用，旨在提高癌症的诊断和治疗水平。我们希望这初步的讨论将引起来自不同学科的科学家的兴趣，以推动 AMM 的发展，并扩大其未来的临床应用。
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