HIV感染患者唾液中总抗氧化能力及抗菌活性的评估
Assessment of Total Antioxidant Capacity and Antimicrobial Activity of in Saliva of HIV-Infected Patients.
作者信息
Aluckal Eby, Ismail Asif, Paulose Anoopa, Lakshmanan Sanju, Balakrishnan M S, Mathew Benoy, M Vikneshan, Kunnilathu Abraham
机构信息
Department of Public Health Dentistry, Mar Baselios Dental College, Kothamangalam, Kerala, India.
Department of Pedodontics, Annoor Dental College and Hospital, Muvattupuzha, Kerala, India.
出版信息
J Pharm Bioallied Sci. 2017 Nov;9(Suppl 1):S237-S240. doi: 10.4103/jpbs.JPBS_141_17.
OBJECTIVES
The objectives of this study were to evaluate the antimicrobial activity and total antioxidant capacity (TAC) of licorice in Saliva of HIV/AIDS patients.
MATERIALS AND METHODS
Saliva specimens were collected from 20 people living with HIV infection, with CD4 count <500 cells/mm from people infected with HIV/AIDS in Mangalore city, India. A combination of amoxicillin-clavulanic acid and nystatin was taken as the positive control and normal saline as negative control. Results were compared using one-way analysis of variance followed by Tukey's analysis in SPSS 19.
RESULTS
The TAC was evaluated spectrophotometrically at 695nm using the phosphomolybdenum method. showed a statistically significant reduction ( < 0.05) in total count. The TAC of was found to be 4.467 mM/L.
CONCLUSIONS
extracts showed good anticandidal activity and also high antioxidant property which reduces the oxidative stress of HIV-infected people.
目的
本研究的目的是评估甘草对印度芒格洛尔市HIV/AIDS患者唾液的抗菌活性和总抗氧化能力（TAC）。
材料与方法
从印度芒格洛尔市20名HIV感染患者中收集唾液标本，这些患者的CD4细胞计数<500个细胞/mm³。将阿莫西林-克拉维酸和制霉菌素的组合作为阳性对照，生理盐水作为阴性对照。在SPSS 19中使用单因素方差分析，随后进行Tukey分析来比较结果。
结果
使用磷钼酸法在695nm处通过分光光度法评估TAC。显示总计数有统计学上的显著降低（<0.05）。发现甘草的TAC为4.467 mM/L。
结论
甘草提取物显示出良好的抗念珠菌活性以及高抗氧化特性，可降低HIV感染者的氧化应激。
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