Eom Hye-Joung, Ko Beom Seok, Song In Hye, Gong Gyungyub, Kim Hak Hee
Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Breast Cancer. 2017 Dec;20(4):404-407. doi: 10.4048/jbc.2017.20.4.404. Epub 2017 Dec 19.
Ectopic breast tissue and male breast cancer are both very rare diseases with only a few reports in the literature. Here, we present the first case of ectopic male breast cancer in the perineum. The patient was a 70-year-old man with a palpable mass in the perineum. A wide local excision and inguinal lymph node dissection revealed invasive breast carcinoma of no special type involving the skin and subcutis, and inguinal lymph node metastases. Immunohistochemical staining showed that the tumor cells were strongly positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Moreover, no p53 overexpression was observed. Herein, the clinical and pathologic features, as well as a review of ectopic male breast cancer are discussed.
异位乳腺组织和男性乳腺癌均为非常罕见的疾病，文献报道较少。在此，我们报告首例会阴部异位男性乳腺癌病例。患者为一名70岁男性，会阴部可触及肿块。广泛局部切除及腹股沟淋巴结清扫显示为非特殊类型的浸润性乳腺癌，累及皮肤和皮下组织，并伴有腹股沟淋巴结转移。免疫组化染色显示肿瘤细胞雌激素和孕激素受体呈强阳性，人表皮生长因子受体2呈阴性。此外，未观察到p53过表达。本文讨论了异位男性乳腺癌的临床和病理特征，并进行了文献复习。
