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卡萨巴赫-梅里特综合征合并高钙血症:一例报告。

Kasabach-Merritt syndrome combined with hypercalcemia: A case report.

作者信息

Zou Runying, Peng Fang, Yu Tian, Zeng Saizhen, You Yalan, Chen Keke, Zou Hui, Tian Xin, Zhu Chengguang, He Xiangling

机构信息

Department of Hematology and Oncology of Children's Medical Center, Hunan Provincial People's Hospital, Changsha, Hunan 410005, P.R. China.

出版信息

Exp Ther Med. 2017 Dec;14(6):6164-6168. doi: 10.3892/etm.2017.5332. Epub 2017 Oct 18.

Abstract

The present case report presented the diagnosis and treatment course of an infant diagnosed with Kasabach-Merritt syndrome (KMS) combined with hypercalcemia (HC). A 35-day-old infant with swelling on the upper right arm for >1 month and thrombocytopenia for 1 day was admitted to Hunan Provincial People's Hospital (Changsha, China) and a series of treatments, including γ-globulin impact, heparin anticoagulation, platelet transfusion, supplement of cryoprecipitate and fibrinogen following heparinization and inhabitation of vascular endothelial cell proliferation by propranolol, were performed. At 2 months after the initial admission to the hospital, surgery was conducted and the hemangioma was removed through pipeline arteriosclerosis embolization when the patient was hospitalized again with symptoms of vomiting and atrophy accompanied by HC. The level of blood calcium reduced to normal following surgery. Cases of KMS combined with HC are extremely rare and the most effective way to treat such cases is surgical resection of the hemangioma.

摘要

本病例报告介绍了一名诊断为卡萨巴-梅里特综合征(KMS)合并高钙血症(HC)的婴儿的诊断和治疗过程。一名35天大的婴儿,右上臂肿胀超过1个月,血小板减少1天,入住湖南省人民医院(中国长沙),并进行了一系列治疗,包括γ球蛋白冲击、肝素抗凝、血小板输注、肝素化后补充冷沉淀和纤维蛋白原以及普萘洛尔抑制血管内皮细胞增殖。首次入院2个月后,患者再次因呕吐和萎缩伴HC症状住院时进行了手术,通过管道动脉硬化栓塞术切除了血管瘤。术后血钙水平恢复正常。KMS合并HC的病例极为罕见,治疗此类病例最有效的方法是手术切除血管瘤。

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