Xuan Han, Gan Chen, Li Wen, Huang Zhonglian, Wang Longsheng, Jia Qianqian, Chen Zhendong, Cheng Huaidong
Department of Oncology, Cancer and Cognition Laboratory, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Oncotarget. 2017 Nov 9;8(62):105648-105661. doi: 10.18632/oncotarget.22358. eCollection 2017 Dec 1.
To investigate the topological organization of functional brain networks in chemotherapy-treated breast cancer (BC) patients with source memory impairment.
Twenty-eight patients with BCfollowingchemotherapyand40age-and education-matched healthy controls (HCs) were recruited in the current study. All participants underwent source memory tests and resting-state functional MRI scans. Individual whole-brain functional brain networks were constructed and analyzed using graph-based network approaches.
Compared with the HCs, the BC patients showed lower scores in the source memory tests ( 0.001).Graph-based analyses revealed that the patients showed higher absolute global and local efficiency (both < 0.01) but lower normalized global and normalized local efficiency (both < 0.001) compared with the HCs. Locally, several prefrontal, occipital, and parietal regions exhibited higher nodal efficiency and functional connectivity in the patients(< 0.05, corrected). Finally, positive correlations were observed between normalized global efficiency and Mini-Mental State Examination scores (r = 0.398, = 0.036) and between normalized local efficiency and the source memory scores (r = 0.497, = 0.01) in the patients.
Chemotherapy-treated BC is associated with abnormal organization of large-scale functional brain networks, which could account for source memory dysfunction in patients with BC.
研究化疗后出现源记忆障碍的乳腺癌（BC）患者功能性脑网络的拓扑组织。
本研究招募了28例化疗后的BC患者以及40名年龄和教育程度匹配的健康对照者（HCs）。所有参与者均接受源记忆测试和静息态功能磁共振成像扫描。使用基于图的网络方法构建并分析个体全脑功能性脑网络。
与HCs相比，BC患者在源记忆测试中的得分较低（<0.001）。基于图的分析显示，与HCs相比，患者的绝对全局和局部效率较高（均<0.01），但归一化全局和归一化局部效率较低（均<0.001）。在局部，患者的几个前额叶、枕叶和顶叶区域表现出较高的节点效率和功能连接性（<0.05，校正后）。最后，在患者中观察到归一化全局效率与简易精神状态检查表得分之间呈正相关（r = 0.398，P = 0.036），以及归一化局部效率与源记忆得分之间呈正相关（r = 0.497，P = 0.01）。
化疗后的BC与大规模功能性脑网络的异常组织有关，这可能是BC患者源记忆功能障碍的原因。
