Ierardo G, Bossù M, D'Angeli G, Celli M, Sfasciotti G
Sapienza, University of Rome, Umberto I University Hospital of Rome, Rome, Italy.
Rare Disease Center Skeletal Dysplasia Bone, Department of Oral and Maxillo Facial Science, DAI Head and Neck UOC Pediatric Dentistry (Dir.: Prof. Antonella Polimeni).
Oral Implantol (Rome). 2017 Nov 30;10(3):311-316. doi: 10.11138/orl/2017.10.3.311. eCollection 2017 Jul-Sep.
To define the possible complications of oral surgery in childhood in patients affected by type 1 Osteogenesis imperfecta (OI) and treated with bisphosphonates (BP).
The study was conducted among 20 patients in childhood with an age range 8-14 (12 ♂ e 8 ♀) affected by OI. Patients were initially evaluated at the Policlinico Umberto I, University Hospital of Rome, Rare Disease Center Skeletal Dysplasia-Bone Metabolic Pathologies and after at the Policlinico Umberto I, University Hospital of Rome, Head and Neck Department, UOC Pediatric Dentistry.
From this experience, we showed that a proper patient management from the medical and dental point of view can protect these patients from the risk of post-operative problems, such as onj, soft tissue flogos, intraoral and extraoral fistulas, failure to heal the post-extractive alveolus, infections, post-operative pain and pathological fractures. The follow-up, ranging from a minimum of 2 years to a maximum of 5 years, have not demonstrated the presence of particular complications or healing defects.
The clinical experiences observed in these patients are encouraging because no postoperative complications have been observed compared to patients non-affected by OI.
明确1型成骨不全症（OI）患儿接受双膦酸盐（BP）治疗后口腔手术可能出现的并发症。
该研究在20例8至14岁的OI患儿中开展（12例男性，8例女性）。患者最初在罗马大学医院翁贝托一世综合医院罕见病中心骨骼发育异常-骨代谢疾病科接受评估，之后在罗马大学医院翁贝托一世综合医院头颈科儿童牙科接受评估。
从该经验来看，我们表明，从医学和牙科角度进行恰当的患者管理可保护这些患者免受术后问题风险，如颌骨坏死、软组织肿胀、口腔内外瘘管、拔牙后牙槽愈合不良、感染、术后疼痛和病理性骨折。随访时间最短2年，最长5年，未发现特殊并发症或愈合缺陷。
在这些患者中观察到的临床经验令人鼓舞，因为与未患OI的患者相比，未观察到术后并发症。
