Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Macromol Biosci. 2018 Feb;18(2). doi: 10.1002/mabi.201700340. Epub 2017 Dec 29.
Stem cells are a promising cell source for regenerative medicine due to their differentiation and self-renewal capacities. In the field of regenerative medicine and tissue engineering, a variety of biomedical technologies have been tested to improve proangiogenic activities of stem cells. However, their therapeutic effect is found to be limited in the clinic because of cell loss, senescence, and insufficient therapeutic activities. To address this type of issue, advanced techniques for biomaterial synthesis and fabrication have been approached to mimic proangiogenic microenvironment and to direct proangiogenic activities. This review highlights the types of polymers and design strategies that have been studied to promote proangiogenic activities of stem cells. In particular, scaffolds, hydrogels, and surface topographies, as well as insight into their underlying mechanisms to improve proangiogenic activities are the focuses. The strategy to promote angiogenic activities of hMSCs by controlling substrate repellency is introduced, and the future direction is proposed.
干细胞因其分化和自我更新能力而成为再生医学中很有前途的细胞来源。在再生医学和组织工程领域，已经测试了多种生物医学技术来提高干细胞的促血管生成活性。然而，由于细胞丢失、衰老和治疗活性不足，它们的治疗效果在临床上受到限制。为了解决这类问题，人们采用了先进的生物材料合成和制造技术来模拟促血管生成的微环境并指导促血管生成的活性。本综述重点介绍了为促进干细胞的促血管生成活性而研究的聚合物类型和设计策略。特别地，支架、水凝胶和表面形貌以及改善促血管生成活性的潜在机制是关注的焦点。引入了通过控制基质斥力来促进 hMSC 血管生成活性的策略，并提出了未来的方向。
