缺氧在干细胞分化和治疗中的作用。
The role of hypoxia in stem cell differentiation and therapeutics.
机构信息
Department of Surgery, Division of Vascular and Endovascular Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
出版信息
J Surg Res. 2011 Jan;165(1):112-7. doi: 10.1016/j.jss.2009.09.057. Epub 2009 Oct 24.
Abstract
Stem cells differentiate into a variety of cell lines, making them attractive for tissue engineering and regenerative medicine. Specific microenvironmental cues regulate self-renewal and differentiation capabilities. Oxygen is an important component of the cellular microenvironment, serving as both metabolic substrate and signaling molecule. Oxygen has been shown to have a variety of effects on embryonic and adult stem cells. This review examines the role of hypoxia in regulating stem cell biology, specifically focusing on growth, maintenance of pluripotency, differentiation, and production of growth factors. Particular attention is paid to hypoxia and stem cells in relation to therapeutic angiogenesis. We conclude that further study is needed to optimize the use of hypoxia as a stimulus for various stem cell functions, including its potential role in therapeutic angiogenesis.
摘要
干细胞可以分化为多种细胞系，使其成为组织工程和再生医学的理想选择。特定的微环境线索调节自我更新和分化能力。氧气是细胞微环境的重要组成部分，既是代谢底物又是信号分子。研究表明，氧气对胚胎和成体干细胞具有多种影响。本综述探讨了缺氧在调节干细胞生物学中的作用，特别是在细胞生长、多能性维持、分化和生长因子产生方面。特别关注缺氧与治疗性血管生成中的干细胞。我们得出结论，需要进一步研究以优化缺氧作为各种干细胞功能的刺激物的使用，包括其在治疗性血管生成中的潜在作用。
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