Esposito Silvano, De Simone Giuseppe
Department of Infectious Diseases, University of Salerno, Italy.
Infez Med. 2017 Dec 1;25(4):301-310.
In recent years the proportion of multi-drug resistance (MDR) among the bacterial pathogens causing infections, particularly those acquired in healthcare settings, has risen worryingly worldwide. It poses a serious public health threat as the multiple patterns of resistance limit the effective treatment options for such infections. Although many bacterial species have developed reduced susceptibility to a wide array of antimicrobial molecules, a particular group of pathogens acronymically referred to as ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) plays a clinically relevant role in the aetiology of life-threatening nosocomial infections. In this review, we represent the rise of MDR among the ESKAPE pathogens over the decades and report studies from each continent showing the current prevalence and burden of such infections worldwide.
近年来，在引起感染的细菌病原体中，尤其是在医疗环境中获得感染的病原体中，多重耐药（MDR）的比例在全球范围内令人担忧地上升。由于多种耐药模式限制了此类感染的有效治疗选择，它对公共卫生构成了严重威胁。尽管许多细菌物种对多种抗菌分子的敏感性已降低，但一组特别的病原体简称为ESKAPE（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）在危及生命的医院感染病因中起着临床相关作用。在本综述中，我们阐述了数十年来ESKAPE病原体中多重耐药的上升情况，并报告了来自各大洲的研究，这些研究显示了此类感染在全球的当前流行情况和负担。
