Kohrman K A, Kirkland J J, Danneman P J
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Rev Infect Dis. 1989 Jan-Feb;11 Suppl 1:S231-6; discussion S236-7. doi: 10.1093/clinids/11.supplement_1.s231.
An experimental infection program was conducted in rabbits, pigs, and baboons with toxic shock syndrome (TSS)-associated and non-TSS-associated strains of Staphylococcus aureus to produce an animal model for TSS. TSS-associated strains of S. aureus--whether positive or negative for TSS toxin 1 (TSST-1)--could not be distinguished from non-TSS-associated strains of S. aureus by means of the rabbit whiffle-ball infection model; therefore, limited pilot infection studies were conducted in pigs and baboons. Experimental conditions were optimized in both the pig and the baboon studies to maximize the chance of producing TSS. Pigs infected with TSS-associated S. aureus strain CDC-11 developed some of the clinical signs observed in TSS (fever, hypotension, diarrhea, and vomiting). However, no changes were detected in clinical chemistry or hematology. Baboons infected with S. aureus strain CDC-11 showed only minimal signs of illness, i.e., lethargy, decreased food intake, and loose stools. TSS was not produced in pigs or baboons, even under optimal exposure conditions.
用与中毒性休克综合征（TSS）相关和不相关的金黄色葡萄球菌菌株在兔、猪和狒狒身上进行了一项实验性感染程序，以建立TSS的动物模型。通过兔高尔夫球感染模型，无法区分TSS毒素1（TSST - 1）呈阳性或阴性的与TSS相关的金黄色葡萄球菌菌株和不与TSS相关的金黄色葡萄球菌菌株；因此，在猪和狒狒身上进行了有限的先导感染研究。在猪和狒狒的研究中优化了实验条件，以最大限度地提高产生TSS的可能性。感染了与TSS相关的金黄色葡萄球菌菌株CDC - 11的猪出现了一些在TSS中观察到的临床症状（发热、低血压、腹泻和呕吐）。然而，临床化学或血液学方面未检测到变化。感染了金黄色葡萄球菌菌株CDC - 11的狒狒仅表现出轻微的疾病迹象，即嗜睡、食物摄入量减少和稀便。即使在最佳暴露条件下，猪和狒狒也未产生TSS。
