Paramonov V V
Cherkasy Regional Oncology Center, Mendeleev str., 7, Cherkasy, 18009, Ukraine.
Probl Radiac Med Radiobiol. 2017 Dec;22:428-449.
The main goal was to analyze the incidence of the morbidity in 1980, 1989, 2001, 2014 years and the structures of the absolute number of hematopoietic and lymphoid neoplasms cases during the period 1980-2014 on radiation contaminated and not contaminated territories in Cherkasy region.
The epidemiological indecies of hematological neoplasms were analyzed on radiation con taminated and not contaminated territories in Cherkasy region during the period from 1980 to 2014. Referring the territory in Cherkasy region to radiation contaminated is based on settlements dosimetry certification of Ukraine after the Chornobyl accident. 63 settlements were enrolled to radiation contaminated areas in Cherkasy region and 11 settlements assigned as not contaminated areas.
The first positions in the list of the hematological neoplasms structure and frequency among new cases during 1980-2014 on not contaminated territories in Cherkasy region occupied by lymphoid leukemia, Hodgkin's lymphoma and myeloid leukemia and on the radiation contaminated territories - chronic, acute lymphoid and myeloid leukemia and lymphoma, diffuse large cell lymphoma. In the structure of hematological neoplasms record ed on the contaminated territories in Cherkasy region, there is a smaller proportion of Hodgkin's lymphoma cases (C81) than 0.84 fold (RR = 0.84; 95 % CI = 0.75-0.93) and more than 1.15 times (RR = 1.15; 95 % CI = 1.02-1.30) other unspecified malignant lymphoid and hematopoietic neoplasms. In 2001 on the radiation contaminated terri tories in Cherkasy region increase the incidence of acute and chronic myeloid leukemia in 2.46 times (p = 0.024) observed compared to non contaminated areas there (5.30 per 100 000, 95% CI = 3.03-8.33 versus 2.15 per 100,000, 95 % CI = 0.66-3.64). It was calculated that RR of acute and chronic myeloid leukemia (C92) in 2001 on radiation contaminated areas in Cherkasy region is 1.40 (95 % CI = 1.12-1.17) and Hodgkin's lymphoma (C81) on condition ally clean areas Cherkasy region - 1.70 (95 % CI = 1.36-2.12).
主要目标是分析1980年、1989年、2001年、2014年切尔卡瑟地区受辐射污染和未受污染地区造血和淋巴系统肿瘤病例的发病率及绝对数结构。
分析1980年至2014年切尔卡瑟地区受辐射污染和未受污染地区血液系统肿瘤的流行病学指标。切尔卡瑟地区受辐射污染的区域是根据切尔诺贝利事故后乌克兰的定居点剂量测定认证确定的。切尔卡瑟地区63个定居点被纳入受辐射污染区域，11个定居点被指定为未受污染区域。
1980 - 2014年切尔卡瑟地区未受污染区域新发病例中，血液系统肿瘤结构和发病率方面，淋巴白血病、霍奇金淋巴瘤和髓细胞白血病位居前列；在受辐射污染区域，慢性、急性淋巴细胞和髓细胞白血病以及淋巴瘤、弥漫性大细胞淋巴瘤位居前列。在切尔卡瑟地区受污染区域记录的血液系统肿瘤结构中，霍奇金淋巴瘤病例（C81）的比例比未受污染区域低0.84倍（RR = 0.84；95% CI = 0.75 - 0.93），其他未特定的恶性淋巴和造血系统肿瘤则比未受污染区域高1.15倍多（RR = 1.15；95% CI = 1.02 - 1.30）。2001年，切尔卡瑟地区受辐射污染区域的急性和慢性髓细胞白血病发病率比未受污染区域增加了2.46倍（p = 0.024）（分别为每10万人5.30例，95% CI = 3.03 - 8.33；每10万人2.15例，95% CI = 0.66 - 3.64）。经计算，2001年切尔卡瑟地区受辐射污染区域急性和慢性髓细胞白血病（C92）的RR为1.40（95% CI = 1.12 - 1.17），切尔卡瑟地区条件清洁区域霍奇金淋巴瘤（C81）的RR为1.70（95% CI = 1.36 - 2.12）。
