Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Division of Biostatistics, Department of Medical Information, Kangbuk Samsung Hospital, Seoul, Republic of Korea.
Retina. 2019 Apr;39(4):753-760. doi: 10.1097/IAE.0000000000002024.
The aim of this was to determine the 5-year incidence of idiopathic epiretinal membrane (ERM) and its risk factors in Korean adults.
A total of 2,152 participants aged 50 years or older enrolled in a health screening program. All participants underwent baseline ophthalmic and systemic examinations in 2006, and were reexamined after 5 years. Epiretinal membranes were diagnosed using fundus photographs taken at baseline and at the 5-year follow-up. The incidence of idiopathic ERM was calculated in this study cohort, and then age-standardized to the 2010 Korean Census. Epiretinal membranes were classified as preretinal macular fibrosis with prominent retinal folds or cellophane macular reflex without retinal folds. Associated risk factors for idiopathic ERM were also analyzed.
Idiopathic ERM developed in 82 of 2,152 participants who had no previous ERM in either eye at baseline. The overall age-standardized incidence was 3.8% (95% confidence interval, 2.8-4.8), including 2.3% with cellophane macular reflex and 1.5% with preretinal macular fibrosis. Multivariate logistic regression analyses revealed that the factors related to the development of idiopathic ERM were age (adjusted odds ratio, 1.04; 95% confidence interval, 1.00-1.08) and hypertriglyceridemia (250 mg/dL or more; adjusted odds ratio, 3.16; 95% confidence interval, 1.54-6.49) after adjusting for confounding factors.
Our results suggest that the 5-year incidence of idiopathic ERM in Korean adults is relatively similar to that in similar-aged white persons. Age and hypertriglyceridemia may increase the risk of developing idiopathic ERM.
本研究旨在确定韩国成年人特发性视网膜内膜（ERM）的 5 年发生率及其危险因素。
共纳入 2152 名年龄在 50 岁及以上的参加健康筛查计划的参与者。所有参与者均于 2006 年进行了基线眼科和全身检查，并于 5 年后再次进行检查。在基线和 5 年随访时拍摄眼底照片来诊断 ERM。本研究队列中计算了特发性 ERM 的发生率，然后按照 2010 年韩国人口普查进行了年龄标准化。将 ERM 分为伴有明显视网膜皱褶的视网膜前纤维膜或无视网膜皱褶的纤维素样黄斑反射。还分析了特发性 ERM 的相关危险因素。
在基线时双眼均无 ERM 的 2152 名参与者中，有 82 名出现了特发性 ERM。总的年龄标准化发生率为 3.8%（95%置信区间，2.8-4.8），其中 2.3%为纤维素样黄斑反射，1.5%为视网膜前纤维膜。多变量逻辑回归分析显示，与特发性 ERM 发生相关的因素为年龄（调整后的优势比，1.04；95%置信区间，1.00-1.08）和高甘油三酯血症（≥250mg/dL；调整后的优势比，3.16；95%置信区间，1.54-6.49），调整了混杂因素后。
我们的研究结果表明，韩国成年人特发性 ERM 的 5 年发生率与年龄相似的白人相似。年龄和高甘油三酯血症可能会增加发生特发性 ERM 的风险。
