Fälth-Magnusson K, Jansson G, Stenhammar L, Sundqvist T, Magnusson K E
Dept. of Pediatrics, University of Linköping, Sweden.
Scand J Gastroenterol. 1989 Jan;24(1):40-6. doi: 10.3109/00365528909092237.
The gastrointestinal permeability was assessed by means of an oral load of a mixture of different-sized polyethylene glycols (PEG 400 and PEG 1000) in 76 children undergoing small-intestinal biopsy because of suspected celiac disease. Children with a mucosal abnormality suggestive of celiac disease had a lower urinary recovery of larger PEG molecules. They also displayed an altered permeability barrier, as evidenced by a lower ratio of recovery between large (1074 Da) and small (370 Da) PEG molecules. Gluten elimination and gluten challenge caused a significant change in PEG recoveries in children undergoing repeated PEG tests. Repeated assessments of intestinal permeability by means of different-sized PEGs after gluten withdrawal and challenge could complement or indicate suitable time for performing small-intestinal biopsy in children with gluten intolerance.
对76名因疑似乳糜泻而接受小肠活检的儿童，通过口服不同大小聚乙二醇（PEG 400和PEG 1000）混合物来评估胃肠道通透性。有提示乳糜泻黏膜异常的儿童，较大PEG分子的尿回收率较低。他们还表现出通透性屏障改变，这可通过大（1074 Da）小（370 Da）PEG分子回收率比值较低得到证明。在接受重复PEG测试的儿童中，去除麸质和麸质激发会导致PEG回收率发生显著变化。在去除麸质和激发后，通过不同大小PEG重复评估肠道通透性，可为麸质不耐受儿童进行小肠活检补充信息或指明合适时间。
