Hamilton I, Hill A, Bose B, Bouchier I A, Forsyth J S
Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland.
J Pediatr Gastroenterol Nutr. 1987 Sep-Oct;6(5):697-701. doi: 10.1097/00005176-198709000-00006.
Passive permeability of small intestine to lactulose and mannitol was studied in children suspected of having intestinal disease, using a hypertonic differential sugar absorption test. Children with coeliac disease and cows' milk intolerance were shown to have an elevated urinary lactulose/mannitol recovery ratio when compared with controls, children with normal jejunal biopsy, or children in whom alternative explanations for failure to thrive had been demonstrated. The abnormality in permeability ratio principally reflects a reduced urinary recovery of mannitol following oral administration. This study demonstrates that a hypertonic sugar absorption test is well tolerated even by young children, is practicable in routine clinical pediatric practice, and is capable of demonstrating abnormal intestinal function in children with small intestinal disease.
利用高渗性差异糖吸收试验，对疑似患有肠道疾病的儿童小肠对乳果糖和甘露醇的被动通透性进行了研究。与对照组、空肠活检正常的儿童或已证实存在发育不良其他原因的儿童相比，患有乳糜泻和牛奶不耐受的儿童尿中乳果糖/甘露醇回收率升高。通透性比值异常主要反映口服后甘露醇尿回收率降低。本研究表明，即使是幼儿也能很好地耐受高渗糖吸收试验，该试验在儿科临床常规实践中切实可行，并且能够显示小肠疾病患儿的肠道功能异常。
