Department of Convergence Korean Medical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Department of Convergence Korean Medical Science, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
J Chin Med Assoc. 2018 Feb;81(2):141-146. doi: 10.1016/j.jcma.2017.04.013. Epub 2017 Dec 26.
Scutellaria baicalensis (SB) is widely used as a medicinal plant to treat various inflammatory diseases. In the present study, we investigated the effects of SB on periodontitis in ligature-induced experimental rat model.
Rats were subjected to a ligature placement around the first molar of the mandible to induce periodontitis. 100 mg/kg SB extracts were orally administered for 14 days. The molar tissues were stained with 1% methylene blue. Histopathological changes of the periodontium were observed by hematoxylin and eosin staining. The levels of cytokines were measured in the gingival tissue.
Alveolar bone resorption was statistically lower in the SB group compared to the ligatured group. SB inhibited the mineralization of cementum. In addition, SB reduced the production of IL-1β, 6, -8 and TNF-α cytokine mRNA expression in gingival tissues.
These results suggest that SB showed ameliorative effects in the ligature-induced periodontitis by inhibition of inflammatory cytokine expression.
黄芩（SB）被广泛用作治疗各种炎症性疾病的药用植物。在本研究中，我们研究了 SB 对结扎诱导的实验性大鼠牙周炎的影响。
大鼠下颌第一磨牙周围放置结扎线以诱导牙周炎。给予 100mg/kg SB 提取物口服 14 天。用 1%亚甲蓝对磨牙组织进行染色。苏木精和伊红染色观察牙周组织的组织学变化。测量牙龈组织中细胞因子的水平。
与结扎组相比，SB 组牙槽骨吸收的统计学意义降低。SB 抑制牙骨质的矿化。此外，SB 减少了牙龈组织中 IL-1β、6、-8 和 TNF-α 细胞因子 mRNA 表达的产生。
这些结果表明，SB 通过抑制炎症细胞因子的表达，对结扎诱导的牙周炎具有改善作用。
