气道微生物宏基因组学。
Airway microbial metagenomics.
机构信息
Clinical Research Group, Clinic for Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
Clinical Research Group, Clinic for Pediatric Pneumology, Allergology, and Neonatology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany; Core Unit 'Genomics', Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
出版信息
Microbes Infect. 2018 Oct-Nov;20(9-10):536-542. doi: 10.1016/j.micinf.2017.12.002. Epub 2017 Dec 26.
High-throughput untargeted metagenome sequencing provides information about the composition of the microbial communities of viruses, bacteria, archaea and unicellular eukaryotes in the habitat of interest. This review outlines the sampling, processing, sequencing and bioinformatic analysis of secretions of the respiratory tract and summarizes our current knowledge of the upper and lower human airways metagenome in health and disease.
高通量非靶向宏基因组测序提供了有关感兴趣生境中病毒、细菌、古菌和单细胞真核生物的微生物群落组成的信息。本文概述了呼吸道分泌物的采样、处理、测序和生物信息学分析，并总结了我们目前对健康和疾病状态下上下呼吸道宏基因组的认识。
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