Zhou Likang, Fei Junhao, Zhang Suping, Shan Tianyu
College of Advanced Materials Engineering, Jiaxing Nanhu University, Jiaxing 314001, China.
Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.
Biosensors (Basel). 2025 Jul 22;15(8):471. doi: 10.3390/bios15080471.
Electrochemiluminescence (ECL) biosensors based on aggregation-induced emission (AIE) emitters have recently emerged as highly sensitive tools for biosensing. The AIE phenomenon, characterized by a significant luminescence change upon aggregation due to restricted intramolecular rotation or vibration, effectively enhances ECL intensity and efficiency, endowing AIECL emitters with high selectivity and stability. This review provides an overview of the developmental trajectory of AIECL, systematically elaborates and comparatively analyzes the mechanisms and luminophore systems of conventional ECL and AIECL, discusses the design strategies and construction methods of AIECL luminophores, and comprehensively summarizes the innovative applications of AIECL in the realm of biosensors. Finally, some of the current challenges in this emerging field are outlined, along with perspectives on future trends.
基于聚集诱导发光（AIE）发光体的电化学发光（ECL）生物传感器最近已成为生物传感的高灵敏度工具。AIE现象的特征是由于分子内旋转或振动受限，聚集时发光发生显著变化，有效地增强了ECL强度和效率，赋予AIECL发光体高选择性和稳定性。本文综述了AIECL的发展轨迹，系统阐述并比较分析了传统ECL和AIECL的机制及发光体体系，讨论了AIECL发光体的设计策略和构建方法，并全面总结了AIECL在生物传感器领域的创新应用。最后，概述了这一新兴领域当前面临的一些挑战以及对未来趋势的展望。
