Department of Cardiac Surgery, Heart and Marfan Center - University of Heidelberg, Heidelberg, Germany.
Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.
Med Sci Monit. 2017 Dec 31;23:6201-6209. doi: 10.12659/msm.905451.
BACKGROUND The aim of this study was to investigate the clinical presentation, operative data, and early and late outcomes of a large patient cohort undergoing surgical treatment for cardiac tumors in our institution. MATERIAL AND METHODS A total of 181 patients underwent surgery because of suspected cardiac tumor in our institution between 1998 and 2016. In 162 cases, the diagnosis was confirmed postoperatively and these patients were included in this study. Preoperative baseline characteristics, operative data, and postoperative early and long-term outcomes were analyzed. RESULTS Mean age at presentation was 56.6±17.6 years, and 95 (58.6%) patients were female. There were 126 (77.8%) patients with benign cardiac tumors, while the remaining patients had malignant tumors (primary and metastasized). The mean follow-up time was 5.2±4.7 years. The most frequent histologically verified tumor type was myxoma (63%, n=102). In terms of malignant tumors, various types of sarcomas presented most primary malignant cardiac tumors (7.4%, n=12). The mean ICU length of stay was 1.7±2.2 days and overall in-hospital mortality was 3.1% (n=5). Frequent postoperative complications included mediastinal bleeding (5.8%, n=9), wound infection (1.3%, n=2), acute renal failure (5.6%, n=9), and major cerebrovascular events (n=7, 4.6%). The overall cumulative survival after cardiac tumor resection was 94% at 30 days, 85% at 1 year, 72% at 5 years, and 59% at 15 years. CONCLUSIONS Surgical treatment of cardiac tumors is a safe and highly effective strategy associated with good early and long-term outcomes.
本研究旨在探讨我们机构中大量接受心脏肿瘤手术治疗的患者的临床表现、手术数据以及早期和晚期结果。
在 1998 年至 2016 年间，我们机构共有 181 例因疑似心脏肿瘤而接受手术治疗的患者。在 162 例患者中，术后诊断得到证实，这些患者被纳入本研究。分析了术前基线特征、手术数据以及术后早期和长期结果。
就诊时的平均年龄为 56.6±17.6 岁，95 例（58.6%）患者为女性。126 例（77.8%）患者患有良性心脏肿瘤，其余患者患有恶性肿瘤（原发性和转移性）。平均随访时间为 5.2±4.7 年。最常见的组织学证实肿瘤类型为黏液瘤（63%，n=102）。在恶性肿瘤中，各种类型的肉瘤构成了大多数原发性恶性心脏肿瘤（7.4%，n=12）。重症监护病房的平均住院时间为 1.7±2.2 天，总住院死亡率为 3.1%（n=5）。常见的术后并发症包括纵隔出血（5.8%，n=9）、伤口感染（1.3%，n=2）、急性肾功能衰竭（5.6%，n=9）和主要脑血管事件（n=7，4.6%）。心脏肿瘤切除术后 30 天、1 年、5 年和 15 年的总体累积生存率分别为 94%、85%、72%和 59%。
心脏肿瘤的外科治疗是一种安全且高效的策略，可获得良好的早期和长期结果。
