Pierce R, Turner-Warwick M
Clin Allergy. 1980 Mar;10(2):229-37. doi: 10.1111/j.1365-2222.1980.tb02101.x.
Delayed skin hypersensitivity responses were elicited in patients with cryptogenic fibrosing alveolitis (CFA) (twenty-eight), asbestosis (eight), mesothelioma (eight) and a "control" group, having miscellaneous lung diseases not normally believed to be associated with T cell deficiency (twenty). Three antigens, Candida albicans, trichophyton and purified protein derivative (PPD) in a range of doses were used. There was no evidence of impaired cellular immunity in CFA or in mesothelioma, indeed there was a significantly increased frequency of reactions to PPD in both of these conditions (P less than 0.05 and P less than 0.01 respectively). There was, however, a trend of decreased responsiveness in the group with asbestosis. The dosage regimen used rarely gave completely negative results (only one of thirty-two completed tests), and may provide a basis for a simple and standard regimen for screening patients suspected of having defective T cell responses.
对隐源性纤维性肺泡炎（CFA）患者（28例）、石棉肺患者（8例）、间皮瘤患者（8例）以及“对照”组（患有通常认为与T细胞缺陷无关的各种肺部疾病，共20例）进行了迟发性皮肤超敏反应检测。使用了三种抗原，即不同剂量的白色念珠菌、毛癣菌和纯化蛋白衍生物（PPD）。没有证据表明CFA或间皮瘤患者存在细胞免疫受损，事实上，在这两种情况下，对PPD的反应频率均显著增加（分别为P<0.05和P<0.01）。然而，石棉肺组存在反应性降低的趋势。所采用的给药方案很少产生完全阴性的结果（32项完成的检测中只有1项），这可能为筛查疑似T细胞反应缺陷患者的简单标准方案提供依据。
