Santrock J, Hatch G E, Slade R, Hayes J M
Department of Chemistry, Indiana University, Bloomington 47405.
Toxicol Appl Pharmacol. 1989 Mar 15;98(1):75-80. doi: 10.1016/0041-008x(89)90135-x.
In this study, 18O3 was used as a tracer for inhaled ozone in mice. The amount of ozone-derived oxygen (ODO) in the lungs was determined by measuring the amount of oxygen-18 in excess of the natural abundance level which remained covalently bound to organic constituents of lung following exposure to 1 ppm 18O3 for less than or equal to 60 min. The rate of disappearance of ODO from the lungs was determined by quantifying the rate of decrease of oxygen-18 in excess of the natural abundance level in lung from mice exposed to 1 ppm 18O3 for 45 min. With exposure to 1 ppm 18O3. ODO accumulated in lung at a rate of 4.38 pmol/mg dry weight/min. Ozone-derived oxygen had a half-life in lung of approximately 6 hr. We estimate that a minimum of 44 pmol of O3 reacted with lung every minute of exposure to 1 ppm O3.
在本研究中，18O3被用作小鼠吸入臭氧的示踪剂。通过测量暴露于1 ppm 18O3小于或等于60分钟后，肺中与肺有机成分共价结合的超过自然丰度水平的氧-18的量，来确定肺中臭氧衍生氧（ODO）的量。通过量化暴露于1 ppm 18O3 45分钟的小鼠肺中超过自然丰度水平的氧-18的减少速率，来确定ODO从肺中消失的速率。暴露于1 ppm 18O3时，ODO在肺中以4.38 pmol/毫克干重/分钟的速率积累。臭氧衍生氧在肺中的半衰期约为6小时。我们估计，每暴露于1 ppm O3一分钟，至少有44 pmol的O3与肺发生反应。
