胰腺癌患者的治疗前血液中性粒细胞/淋巴细胞比值与转移相关，并可预测生存情况。

Pretreatment blood neutrophil/lymphocyte ratio is associated with metastasis and predicts survival in patients with pancreatic cancer.

作者信息

Guo Jing, Wu Mengwan, Guo Lihong, Zuo Qiang

机构信息

Southern medical university, Nanfang hospital, department of oncology, Guangzhou, Guangdong Province, China.

出版信息

Bull Cancer. 2018 Feb;105(2):146-154. doi: 10.1016/j.bulcan.2017.10.028. Epub 2017 Dec 28.

DOI:10.1016/j.bulcan.2017.10.028

PMID:29290332

Abstract

BACKGROUND

The predictive value of systemic inflammatory markers has been explored in various types of cancer. In the present study, we aimed to investigate the association between pretreatment neutrophil/lymphocyte ratio (NLR) and tumor metastasis in pancreatic cancer, and the values of NLR as a prognostic factor of overall survival.

METHODS

Clinical and laboratory data from 256 consecutive pancreatic cancer patients were analyzed retrospectively. The NLR was recorded before treatment and analyzed along with clinicopathological characteristics and overall survival of pancreatic cancer patients.

RESULTS

Multivariate analysis revealed that pretreatment NLR (HR: 2.393; 95% CI: 1.326-4.320; P=0.004) was an independent risk factor for distant metastasis. Furthermore, COX regression analysis showed that in addition to pretreatment NLR (HR: 1.871; 95% CI: 1.413-2.477; P<0.001), metastasis and stage were independent prognostic factors.

CONCLUSION

Pretreatment NLR values were significantly associated with distant metastasis in pancreatic cancer patients. Higher NLR values were detected in metastatic disease and may be an independent prognostic factor of overall survival in pancreatic cancer patients.

摘要