Zhu Dan-Dan, Liu Xun
Department of Ophthalmology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing, China.
J Ophthalmol. 2019 Oct 31;2019:6043612. doi: 10.1155/2019/6043612. eCollection 2019.
. To evaluate the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio(PLR) value in the development of branch retinal vein occlusion (BRVO)patients.
81 patients with BRVO and 81 age and sex-matched subjects were recruited as the control group. The BRVO diagnosis was confirmed under comprehensive ophthalmologic examinations. NLR and PLR parameters obtained from peripheral blood were recorded.
Both the mean NLR and PLR was significantly higher in the BRVO group compared with the control group ( < 0.001). In ROC analysis, the AUC for NLR was 0.82, and NLR of >2.48 predicted BRVO with a sensitivity of 58% and specificity of 98%. The AUC for PLR was 0.78, and PLR of >110.2 predicted BRVO with a sensitivity of 72% and specificity of 72%.
The current study demonstrated that BRVO patients had increased NLR and PLR levels compared with control subjects. The NLR and PLR may be used as independent predictors for identifying risk for the development of BRVO.
评估中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）在视网膜分支静脉阻塞（BRVO）患者病情发展中的价值。
招募81例BRVO患者和81例年龄及性别匹配的受试者作为对照组。通过全面的眼科检查确诊BRVO。记录外周血中的NLR和PLR参数。
与对照组相比，BRVO组的平均NLR和PLR均显著更高（<0.001）。在ROC分析中，NLR的AUC为0.82，NLR>2.48预测BRVO的敏感度为58%，特异度为98%。PLR的AUC为0.78，PLR>110.2预测BRVO的敏感度为72%，特异度为72%。
当前研究表明，与对照组相比，BRVO患者的NLR和PLR水平升高。NLR和PLR可作为识别BRVO发生风险的独立预测指标。
