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本文引用的文献

1
Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.耗尽 SIRT6 的酶活性会增加急性髓细胞白血病细胞对 DNA 损伤剂的敏感性。
Haematologica. 2018 Jan;103(1):80-90. doi: 10.3324/haematol.2017.176248. Epub 2017 Oct 12.
2
SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b.SIRT6 通过调控 Lin28b 抑制胰腺癌。
Cell. 2016 Jun 2;165(6):1401-1415. doi: 10.1016/j.cell.2016.04.033. Epub 2016 May 12.
3
SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway.SIRT6 过表达通过 BCL2 相关 X 蛋白依赖的凋亡途径增强肝癌细胞逃避凋亡。
Clin Cancer Res. 2016 Jul 1;22(13):3372-82. doi: 10.1158/1078-0432.CCR-15-1638. Epub 2016 Feb 9.
4
SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.SIRT6使丙酮酸激酶M2(PKM2)去乙酰化,以抑制其核定位和致癌功能。
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E538-47. doi: 10.1073/pnas.1520045113. Epub 2016 Jan 19.
5
Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.SIRT6 和 miR-122 之间的相互调节控制肝脏代谢并预测肝癌预后。
Cell Rep. 2016 Jan 12;14(2):234-42. doi: 10.1016/j.celrep.2015.12.023. Epub 2015 Dec 31.
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The complex role of SIRT6 in carcinogenesis.SIRT6在致癌过程中的复杂作用。
Carcinogenesis. 2016 Feb;37(2):108-18. doi: 10.1093/carcin/bgv167. Epub 2015 Dec 30.
7
Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.组蛋白去乙酰化酶SIRT6在多发性骨髓瘤细胞DNA损伤反应中作用的证据。
Blood. 2016 Mar 3;127(9):1138-50. doi: 10.1182/blood-2015-06-649970. Epub 2015 Dec 16.
8
E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells.E2F1通过抑制癌细胞中Sirt6的转录来增强糖酵解。
Oncotarget. 2015 May 10;6(13):11252-63. doi: 10.18632/oncotarget.3594.
9
The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells.RUNX2转录因子负向调节SIRT6表达以改变乳腺癌细胞中的葡萄糖代谢。
J Cell Biochem. 2015 Oct;116(10):2210-26. doi: 10.1002/jcb.25171.
10
The histone deacetylase SIRT6 inhibits ovarian cancer cell proliferation via down-regulation of Notch 3 expression.组蛋白去乙酰化酶SIRT6通过下调Notch 3表达抑制卵巢癌细胞增殖。
Eur Rev Med Pharmacol Sci. 2015;19(5):818-24.

The role of SIRT6 in tumors.

作者信息

Desantis Vanessa, Lamanuzzi Aurelia, Vacca Angelo

机构信息

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "G. Baccelli", University of Bari Medical School, Policlinico, Bari, Italy.

Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine "G. Baccelli", University of Bari Medical School, Policlinico, Bari, Italy

出版信息

Haematologica. 2018 Jan;103(1):1-4. doi: 10.3324/haematol.2017.182675.

DOI:10.3324/haematol.2017.182675
PMID:29290628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5777184/
Abstract
摘要